Fudan University Cancer Center Multistep processed accomplished by metastasizing cancer Motility and tissue invasion Intravasation(Alternatively, can enter lymphatic vessels "Survival in the blood stream(trauma, immune cells, oxygen levels growth factor availability etc -Arrest at new location Extravasation Attraction/induction of new stromal cells(may occur BEFORE metastasis occurs. Growth and Proliferation.. Angiogenesis 复旦大学上海医学院肿瘤学系复旦大学上海医学院肿瘤学系 Fudan University Cancer Center Multistep processed accomplished by metastasizing cancer ▪Motility and tissue invasion ▪Intravasation (Alternatively, can enter lymphatic vessels) ▪Survival in the blood stream (trauma, immune cells, oxygen levels, growth factor availability etc.) ▪Arrest at new location ▪Extravasation ▪Attraction/induction of new stromal cells (may occur BEFORE metastasis occurs). ▪Growth and Proliferation…. Angiogenesis