Fudan University Cancer Center Multistep Process of Metastasis Detachment from primary tumor Metastasis is influenced by the interactions between i Infiltration of A O Tumor cells and host cells Intravasation into blood syste i ECM Integrins O Immediate and extended Cadherins tumor microenviroments Association with leukocytes and platelet Extravasation Metastasis Mandi murph, research on Melanoma 复旦大学上海医学院肿瘤学系复旦大学上海医学院肿瘤学系 Fudan University Cancer Center Multistep Process of Metastasis Metastasis is influenced by the interactions between ⚫ Tumor cells and host cells ⚫ Immediate and extended tumor microenviroments Mandi Murph, Research on Melanoma