C.Ciliary movement D.Phagocytic activity by macrophages The structure of centrioles 35.A 53-year-old man with a body mass index of 30 is diagnosed with type ll diabetes.Clinical studies have demonstrated that chloroquine improves glucose metabolism in such patients.Chloroquine is a weak base that neutralizes acidic organelles.In a pancreaticBcell,which one of the following would be a direct effect of chloroquine treatment? A.Increased proinsulin content in secretory vesicles B.Increased release of C peptide C.Increaesd number of amylase-containing secretory vesicles? d.Reduced translation of glucagon mrNA E.Increased stability of insulin mRNA 36.A 32-year-old man and his 30-year-old wife are referred for a reprocuctive endocrinology infertility (REl)consult after 2 years of trying to"get pregnant".He is diagnosed with oligozoospermia.Ejaculated mature sperm are collected and analyzed for genetic analysis.Using genetic linkage analysis,his REI specialist determines that he has aberrations in genic meiotic recom ination,including both diminished frequency and suboptimal oction,resulting ina high of aneuploid sperm.In the explamation of the problem. .she explains meiosis and recombination attributing the problem to a specific phase of meiosis.Which phase of meiosis is most closely associated with recombination? A.Lepotene B.Zygotene C.Pachytene D.Diplotene E.Diakinesis 37.A32-year-old (gravida2.para2)woman who gave birth toa baby girl 24 hours before is having difficulty urinating and is retaining urine in her bladder.She is given bethanechol,a muscatinic agonist,which is the ligand shown in the figure below.Which one of the following is the function of molecule A? A directly activates protein kinaseC B Binds to the ER C Hydrolysis of PIP toform diacylglycerol (DAG)and inositol triphosphate(IP3) 4.5-bisphosphate (PIP2) E Stimulation of Gs activity through phosphorylation of PIP2C. Ciliary movement D. Phagocytic activity by macrophages E. The structure of centrioles 35. A 53-year-old man with a body mass index of 30 is diagnosed with typeⅡdiabetes. Clinical studies have demonstrated that chloroquine improves glucose metabolism in such patients. Chloroquine is a weak base that neutralizes acidic organelles. In a pancreaticβcell , which one of the following would be a direct effect of chloroquine treatment ? A.Increased proinsulin content in secretory vesicles B. Increased release of C peptide C. Increaesd number of amylase-containing secretory vesicles? D. Reduced translation of glucagon mRNA E. Increased stability of insulin mRNA 36. A 32-year-old man and his 30-year-old wife are referred for a reprocuctive endocrinology infertility (REI)consult after 2 years of trying to “get pregnant”. He is diagnosed with oligozoospermia. Ejaculated mature sperm are collected and analyzed for genetic analysis. Using genetic linkage analysis , his REI specialist determines that he has aberrations in spermatogenic meiotic recombination, including both diminished frequency and suboptimal location, resulting in a high frequency of aneuploid sperm. In the explamation of the problem, she explains meiosis and recombination attributing the problem to a specific phase of meiosis . Which phase of meiosis is most closely associated with recombination? A. Lepotene B. Zygotene C. Pachytene D. Diplotene E . Diakinesis 37. A 32-year-old (gravida2, para2) woman who gave birth to a baby girl 24 hours before is having difficulty urinating and is retaining urine in her bladder. She is given bethanechol, a muscatinic agonist , which is the ligand shown in the figure below . Which one of the following is the function of molecule A ? A directly activates protein kinase C B Binds to the ER C Hydrolysis of PIP2 to form diacylglycerol (DAG) and inositol triphosphate (IP3) D Stimulation of inhibitory G protein (Gi) activity through phosphorylation of phosphatidylinositol 4,5-bisphosphate (PIP2) E Stimulation of G5 activity through phosphorylation of PIP2