38.A 20-month-old boy is diagnosed with Hutchinson-Gilgord progerial syndrome (HGPS),a severe form of premature aging.Fetal and early postnatal developmentare normal,but there is now severe failureo thrive,some lipoatrophy,bo ony abnormalities,a smal beaked ose and edin ssand speckled hypopigmentation with some areas of tight hard skin.His neurological and cognitive tests are normal Genetic analysis shows a single spontaneous mutation in codon 608 of the LMNA gene,which encodes both lamin A and lamin C.Which one of the following would you most likely expect to be a direct effect in cells obtained from this patient A Increased heter B Interference with microtubule treadmilling CIncreased synthesis of rRNA in the D Loss of ability to adhere to the basement membrane through integrins E Aberrations in nuclear architecture 39.The two major secretory pathways A -B-C-D(pathway I and C-E(pathway lI)are illustrated in the figure.Albumin ation by by pathway I In a patient with serum evels of albumin are reduced.Which one of the following is the most likely cause of the reduced secretion of albumin? A ① A.Reduced binding of“A”to receptors D.Reduced activity of the cAMP-actived signal transduction system E.Increased cAMP levels 40.AG phase and an M-phase cell are fused together with a endai virus.The result is thar the chromosomes in the G-phase cell condense.Which of the follo A. Lamins will be phosphorylated in the G cell B.The S-phase activator will be expressed in the M-phase cell C.The M-phase cell will reduplicate its DNA 38. A 20-month-old boy is diagnosed with Hutchinson-Gilgord progerial syndrome (HGPS) , a severe form of early-onset premature aging . Fetal and early postnatal development are normal , but there is now severe failure to thrive , some lipoatrophy , bony abnormalities , a small , beaked nose and receding mandible , hair loss , and speckled hypopigmentation with some areas of tight hard skin . His neurological and cognitive tests are normal . Genetic analysis shows a single spontaneous mutation in codon 608 of the LMNA gene , which encodes both lamin A and lamin C . Which one of the following would you most likely expect to be a direct effect in cells obtained from this patient ? A Increased heterochromatin B Interference with microtubule treadmilling C Increased synthesis of rRNA in the nucleolus D Loss of ability to adhere to the basement membrane through integrins E Aberrations in nuclear architecture 39. The two major secretory pathways A B C D（pathwayⅠ）and C E (pathwayⅡ) are illustrated in the figure . Albumin secreation by hepatocytes occurs by pathwayⅡ. In a patient with cirrhosis , the serum levels of albumin are reduced. Which one of the following is the most likely cause of the reduced secretion of albumin? A. Reduced binding of “A” to receptors B. Reduced numbers of functional hepatocytes C. Down-regulation of “B” on hepatocytes D. Reduced activity of the cAMP-actived signal transduction system E. Increased cAMP levels 40. A G1 phase and an M-phase cell are fused together with a Sendai virus. The result is thar the chromosomes in the G1-phase cell condense. Which of the following would be the best possible cell biological explanation ? A. Lamins will be phosphorylated in the G1 cell B. The S-phase activator will be expressed in the M-phase cell C. The M-phase cell will reduplicate its DNA