D.The Gl/S-CdK complex will be activated in the M-phase cell E Are-replication block will occur in the Gl-phase cell 41.Consider the amino acid shown below.The configuration about which atom will determine whether the amino acid is in the Dor Lconfiguration? A OH CH2 O H2N- C-OH B H 42.Which of the following amino acids are belonged to the acidic amino acids? (A)Phe Tyr (B)Met Cys (C)Leu lle (D)GluAsp (E)Gly Ala 43.The covalent bond formed between the carboxyl group of one amino acid and the amino group of another amino acid is called (A)Phosphoester bond (B)phosphodiester bond (C)Peptide bond (D)Glycosidic bond (E) Thioester bond 44.A part of protein sequence that can form a compact three-dimensional structure and often can be independently folded is called (A)Residue (B)Secondary structure (C)Motif (D)Domain (E)Subunit 45.An-mninfant ehibits lthargy.Physical exam detects ork display a microcytic anemia with abnormal,sickle-shaped red blood cells.This defect is most likely due to a hereditary mutation in which of the following? A Hemoglobin B Glucose-6-phosphate dehydrogenase C Pyruvate kinase D Fructose 1.6-biphosphatase E Methemoglobin reductase 46 a patient has been n sed with col cer The atient with a combination of cher othe peutic drug drug because it inhibits which 一合(P)1asta。 the 47 A 6-month-old infant is seen by the pediatrician for developmental delay Blood work shows megaloblastic anemia,although measu ments of Band folate are in the highnomal ange.Urinalysisd monstrates,upon standing thef virtually all of the clinical problems.The crystalline substance was most likely composed of which of the following? A.Uracil B.Thymine C.Orotate D.Aspartate E.Cytosine has also developed gout due to an increase in the levels of which of the following metabolites? A.PRPP B.Glutamine C.ATP D.NADH E.dTTPD . The G1/S-CdK complex will be activated in the M –phase cell E A re-replication block will occur in the G1- phase cell 41. Consider the amino acid shown below. The configuration about which atom will determine whether the amino acid is in the D or L configuration? 42. Which of the following amino acids are belonged to the acidic amino acids? (A) Phe Tyr (B) Met Cys (C) Leu Ile (D) Glu Asp (E) Gly Ala 43. The covalent bond formed between the carboxyl group of one amino acid and the amino group of another amino acid is called______. (A) Phosphoester bond (B) phosphodiester bond (C) Peptide bond (D) Glycosidic bond (E) Thioester bond 44. A part of protein sequence that can form a compact three-dimensional structure and often can be independently folded is called ______. (A) Residue (B) Secondary structure (C) Motif (D) Domain (E) Subunit 45. An 8-month-old infant exhibits jaundice and lethargy. Physical exam detects splenomegaly. Blood work display a microcytic anemia with abnormal, sickle-shaped red blood cells. This defect is most likely due to a hereditary mutation in which of the following? A Hemoglobin B Glucose-6-phosphate dehydrogenase C Pyruvate kinase D Fructose 1,6-biphosphatase E Methemoglobin reductase 46. A patient has been recently diagnosed with colorectal cancer.The physician treats the patient with a combination of chemotherapeutic drugs, one of which is5-fluorouracil(5-FU). 5-FU is effective as an anticancer drug because it inhibits which one of the following enzymes? A. Dihydrofolate reductase B. Thymidylate synthase C. Amidophosphoribosyl transferase D. 5'-phosphoribosyl 1'-pyrophosphate(PRPP) synthetase E. UMP synthase 47 A 6-month-old infant is seen by the pediatrician for developmental delay.Blood work shows megaloblastic anemia, although measurements of B12 and folate are in the high normal range. Urinalysis demonstrates, upon standing, the formation of a crystalline substance. Supplementation of the child's diet with uridine reversed virtually all of the clinical problems.The crystalline substance was most likely composed of which of the following? A. Uracil B. Thymine C. Orotate D. Aspartate E. Cytosine 48. A patients exhibits fasting hypoglycemia and lactic acidosis under fasting conditions. Hepatomegaly is also evident. A glucagon challenge only releases about 10% of the expected level of glucose from the liver. The patient has also developed gout due to an increase in the levels of which of the following metabolites? A. PRPP B. Glutamine C. ATP D. NADH E. dTTP