49.Your 6-year-od female patient has psoriasis and has been treated with methotrexate for several years.She have all been normal.She has developed an anemia.Which of following would you expect to find when working uo her anemia? A.A macrocytic anemia B A microcytic anemia C Thalassemia D Spherocytes E A low vitamin B12 level 50.A researcher wants to developa method of labeling purines uure studies.Purine synthesis will be done in a test tube using only the enzymes necessary to synthesize purines via the de novo pathway.Which starting materials should be labeled with the heavy nitrogen in order to maximizeN incorporation into purines? A.Aspartate.glycine,and glutamate B.Aspartate.glycine,and N5-formimino tetrahydrofolate C.Asparagine.glycine,and glutamine D.Asparagine.glutamate,and glutamine E.Aspartate,glycine,and glutamine 51 Which of the following lipoproteins can transfer extrahepatic cholesterol to liver for metabolism? A CM B LDL C HDL D IDL E VLDL 52.Which of the following compounds can not be metabolized into Acetyl-CoA? A.Ketone bodies B.Fatty acids C.Cholesterol D.phospholipids E.glucose 53.Fatty acids can be oxidized into acetyl-CoA.which is the following is the fate for acetyl-CoA? c For synthesis of fatty acids B.to provide er For synthesis of ketone bodies D.For synthesis of cholestero E.All of the above 54.Which is the following is transformed from cholesterol: A.Vitamin A B.Vitamin PP C.Vitamin C D.Vitamin D3 E.Vitamin E 55.Which is the following is the function of acyl carrer protein(ACP) A.Transferring cholesterol B.Activating lipoprotein lipase C The core of fatty acid synthase system DTransferring fatty acids E.Carrying carbon unit 56.Which is the following can transfer acetyl group from mitochondria to cvtoplasm A.Acetyl-CoA B.Acetyl-carnitine C.Succinate D.Citric acid E.Oxaloacetate 57.After produced in the liver,fats are mainly used for which one of the following processes? A.Hydrolyzed in liver B.Stored in liver C.Oxidized and provide ATP in liver D.Combined with apolipoprotein to form VLDL E.All of above are wrong 58Which of the plasma lipoproteins is best described as follows:synthesized in the intestinal mucosa containinga high concentration of triacylglycerol and mainly cleared from the circulation by adipose tissue and muscle A.Chylomicrons B.High-density lipoprotein C.Intermediate density lipoprotein D Low-density lipoprotein E.Very low-density lipoprotein 49. Your 60-year-old female patient has psoriasis and has been treated with methotrexate for several years. She has no other medical problems and her preventive screenings, including fetal occult blood tests and colonoscopy, have all been normal. She has developed an anemia. Which of following would you expect to find when working uo her anemia? A. A macrocytic anemia B A microcytic anemia C Thalassemia D Spherocytes E A low vitamin B12 level 50. A researcher wants to develop a method of labeling purines with 15N for use in future spectroscopic studies.Purine synthesis will be done in a test tube using only the enzymes necessary to synthesize purines via the de novo pathway. Which starting materials should be labeled with the heavy nitrogen in order to maximize 15N incorporation into purines? A. Aspartate,glycine,and glutamate B. Aspartate,glycine,and N5-formimino tetrahydrofolate C. Asparagine,glycine,and glutamine D. Asparagine,glutamate,and glutamine E. Aspartate,glycine,and glutamine 51 Which of the following lipoproteins can transfer extrahepatic cholesterol to liver for metabolism? A. CM B. LDL C. HDL D. IDL E. VLDL 52.Which of the following compounds can not be metabolized into Acetyl-CoA? A. Ketone bodies B. Fatty acids .C. Cholesterol D.phospholipids E. glucose 53.Fatty acids can be oxidized into acetyl-CoA, which is the following is the fate for acetyl-CoA? A. For synthesis of fatty acids B.For oxidization to provide energy C For synthesis of ketone bodies D.For synthesis of cholesterol E. All of the above 54.Which is the following is transformed from cholesterol: A. Vitamin A B.Vitamin PP C.Vitamin C D.Vitamin D3 E.Vitamin E 55.Which is the following is the function of acyl carrer protein (ACP) A. Transferring cholesterol B. Activating lipoprotein lipase C The core of fatty acid synthase system D Transferring fatty acids E.Carrying carbon unit 56.Which is the following can transfer acetyl group from mitochondria to cytoplasm A. Acetyl-CoA B. Acetyl-carnitine C.Succinate D. Citric acid E.Oxaloacetate 57.After produced in the liver, fats are mainly used for which one of the following processes? A.Hydrolyzed in liver B.Stored in liver C. Oxidized and provide ATP in liver D.Combined with apolipoprotein to form VLDL E. All of above are wrong 58.Which of the plasma lipoproteins is best described as follows: synthesized in the intestinal mucosa, containing a high concentration of triacylglycerol and mainly cleared from the circulation by adipose tissue and muscle? A. Chylomicrons B.High-density lipoprotein C.Intermediate density lipoprotein D Low-density lipoprotein E.Very low-density lipoprotein