1.教学目标 (1)Define oral drug absorptionand describe the absorptionprocess. (2)Introduce two generalapproaches used for studyingabsorption kinetics and theirsimilarities and differences. (3)Understand the basic principlesfor physiologically basedabsorption kinetics. (4)Describe the oral onecompartment model andexplain how this modelsimulates drug absorption fromthe gastrointestinal tract. (5)Calculate the pharmacokineticparameters of a drugthat follows the oral onecompartment model,the fraction of drugabsorbed in a one-compartmentmodel using the Wagner-Nelsonmethod. 2.教学重难点 Understand the oral drug absorption principles and process,the basic principles for physiologically based absorption kinetics,calculate the pharmacokinetic parameters of a drug that follows the oral one compartment model. 3.教学内容 Basic principles of physiologically based absorption kinetics (bottom-up approach),absorption kinetics (the top-down approach),pharmacokinetics of drug absorption,significance of absorption rate constants, zero-order absorption model,first-order absorption model. 4.教学方法 (1)Teaching method:Relevant concepts and theoretical framework,combined with typical drug examples. (2)Discussion method:Flipped classroom was encouraged. 5.教学评价 Take quick summary test,discuss with selected learning questions and frequently asked questions.1.教学目标 (1) Define oral drug absorptionand describe the absorptionprocess. (2) Introduce two generalapproaches used for studyingabsorption kinetics and theirsimilarities and differences. (3) Understand the basic principlesfor physiologically basedabsorption kinetics. (4) Describe the oral onecompartment model andexplain how this modelsimulates drug absorption fromthe gastrointestinal tract. (5) Calculate the pharmacokineticparameters of a drugthat follows the oral onecompartment model, the fraction of drugabsorbed in a one-compartmentmodel using the Wagner–Nelsonmethod. 2.教学重难点 Understand the oral drug absorption principles and process, the basic principles for physiologically based absorption kinetics, calculate the pharmacokinetic parameters of a drug that follows the oral one compartment model. 3.教学内容 Basic principles of physiologically based absorption kinetics (bottom-up approach), absorption kinetics (the top-down approach), pharmacokinetics of drug absorption, significance of absorption rate constants, zero-order absorption model, first-order absorption model. 4.教学方法 (1) Teaching method: Relevant concepts and theoretical framework, combined with typical drug examples. (2) Discussion method: Flipped classroom was encouraged. 5.教学评价 Take quick summary test, discuss with selected learning questions and frequently asked questions