吴凌峰,等成体神经于细胞与微环境 CIOR wWcTER org 44 Pumiglia K, Temple S PEDF: bridging neurovascular [55] Oya S, Yoshikawa G, Takai K, et al. Attenuation of Notch interactions in the stem cell niche. Nat neurosci signaling promotes the differentiation of neural progenitors 20069(3)299300. into neurons in the hippocampal CAl region after ischemic [45 Lim DA, Tramontin AD, Trevejo JM, et al. Noggin antagonizes BMP signaling to create a niche for adult neurogen [56] Aguirre A, Rubio ME, Gallo V Notch and EGFR pathway teraction regulates neural stem cell number and [46] Sawamoto K, Wichterle H, Gonzalez-Perez o, et al. New self-renewal. Nature.2010:467(7313):323-327 neurons follow the flow of cerebrospinal fluid in the adult brain. [57 Guo YJ, Zhang ZJ, Wang SH, et al. Notch1 signaling Science.2006311(5761)629632. hippocampal neurogenesis and behavioral responses to [47 Viapiano MS, Matthews RT From barriers to bridges chronic unpredicted mild stress in adult ischemic rats. Prog hondroitin sulfate proteoglycans in neuropathology. Trends ychiatry.200933(4)688694 Mol med.2006:12(10)488496 [58]Kageyama R, Ohtsuka T, Hatakeyama J, et al. Roles of bHLH [48Kerever A, Schnack J, Vellinga D, et al. Novel extracellular enes in neural stem cell differentiation. Exp Cell Res 2005 matrix structures in the neural stem cell niche capture the 306(2):343348 neurogenic factor fibroblast growth factor 2 from the 59 Watt FM, Hogan BL. Out of Eden: stem cells and their niches. extracellular milieu. Stem Cells. 2007; 25(9): 2146-2157. cience.2000;287(5457):1427-1430 [49] Niola F, Zhao X, Singh D, et al. Id proteins synchronize [60] Veizovic T, Beech JS, Stroemer RP, et al. Resolution of stroke stemness and anchorage to the niche of neural stem cells deficits following contralateral grafts of conditionally immortal Nat cell biol.2012:14(5)477487 neuroepithelial stem cells. Stroke. 2001: 32(4): 1012-1019 [50] Fuchs E, Tumbar T, Guasch G Socializing with the neighbors: [61] Merkle FT, Mirzadeh Z, Alvarez-Buylla A Mosaic organization stem cells and their niche. Cell. 2004; 116(6): 769-778. of neural stem cells in the adult brain Science. 2007. 317 [51] Choi KC, Yoo DS, Cho Ks, et al. Effect of single growth factor (5836):381-384 and growth factor combinations on differentiation of neural [62 De Marchis S, Bovetti S, Carletti B, et al. Generation of stem cells. J Korean Neurosurg Soc. 2008: 44(6): 375-381 distinct types of periglomerular olfactory bulb interneurons 52 Joseph D'Ercole A, Ye P. Expanding the mind: insulin-like during development and in adult mice: implication for intrinsic rowth factor I and brain development. Endocrinology properties of the subventricular zone progenitor population. J 2008;149(12)59585962 Neurosc.2007;27(3)657-664 53 Singh AM, Reynolds D, Cliff T, et al. Signaling network [63] Nishino H, Hida H, Takei N, et al. Mesencephalic neural stem crosstalk in human pluripotent cells: a Smad2/3-regulated (progenitor) cells develop to dopaminergic neurons more switch that controls the balance between self-renewal and strongly in dopamine-depleted striatum than in intact striatum differentiation Cell Stem Cell. 2012: 10(3)- 312-326 xp Neurol.2000;164(1)209214 [54] Tsarovina K, Schellenberger J, Schneider C, et al. Progenitor [64] Kelsch W, Mosley CP, Lin CW, et al. Distinct mammalian cell maintenance and neurogenesis in sympathetic ganglia precursors are committed to generate neurons with defined nvolves Notch signaling. Mol Cell Neurosci dendritic projection patterns. PLoS BioL. 2007, 5 (11): e300 2008:37(1)20-31 /SSN 2095-4344 CN 21-1581/R CODEN: ZLKHAH o1994-2013ChinaAcademicJournalElectronicPublishingHouse.Allrightsreservedhttp:/www.cnki.net吴凌峰，等. 成体神经干细胞与微环境 ISSN 2095-4344 CN 21-1581/R CODEN: ZLKHAH 3545 www.CRTER.org [44] Pumiglia K, Temple S. 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Socializing with the neighbors: stem cells and their niche. Cell. 2004;116(6):769-778. [51] Choi KC, Yoo DS, Cho KS, et al. Effect of single growth factor and growth factor combinations on differentiation of neural stem cells. J Korean Neurosurg Soc. 2008;44(6):375-381. [52] Joseph D'Ercole A, Ye P. Expanding the mind: insulin-like growth factor I and brain development. Endocrinology. 2008;149(12):5958-5962. [53] Singh AM, Reynolds D, Cliff T, et al. Signaling network crosstalk in human pluripotent cells: a Smad2/3-regulated switch that controls the balance between self-renewal and differentiation. Cell Stem Cell. 2012;10(3):312-326. [54] Tsarovina K, Schellenberger J, Schneider C, et al. Progenitor cell maintenance and neurogenesis in sympathetic ganglia involves Notch signaling. Mol Cell Neurosci. 2008;37(1):20-31. [55] Oya S, Yoshikawa G, Takai K, et al. 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