吴凌峰,等成体神经于细胞与微环境 Www.crTer.org Song X, Zhu CH, Doan C, et al. Germline stem cells anchored [28] Tavazoie M, Van der Veken L, Silva-Vargas V, et al. A by adherens junctions in the Drosophila ovary niches specialized vascular niche for adult neural stem cells. Ce Science.2002296(5574):1855-1857 Stem Cell.2008:3(3):279288 [10] Doetsch F. A niche for adult neural stem cells. Curr Opin [29 Shen Q, Wang Y, Kokovay E, et al. Adult SVZ stem cells lie in Genet Dev2003;13(5):543-550 a vascular niche: a quantitative analysis of niche cell-cell [11 Arai F, Hirao A, Suda T Regulation of hematopoiesis and its interactions. Cell Stem Cell. 2008, 3(3): 289-300 interaction with stem cell niches. Int J Hematol. 2005; 2(5): [30] Teng H, Zhang ZG Wang L, et al. Coupling of angiogenesis 371-376. and neurogenesis in cultured endothelial cells and neural [12] Sakaguchi M, Imaizumi Y, Okano H Expression and function progenitor cells after stroke. J Cereb Blood Flow Metab 2008 of galectin-1 in adult neural stem cells. Cell Mol Life Sci. 2007; 28(4)764-771 [31]Shen Q, Goderie SK, Jin L, et al. Endothelial cells stimulate [13] Lendahl U, Zimmerman LB, McKay RD CNS stem cells elf-renewal and expand neurogenesis of neural stem cells xpress a new class of intermediate filament protein. Cell Science.2004:304(5675):1338-1340 199060(4)585595 [32 Nikolova G, Strilic B, Lammert E The vascular niche and its [14]Kaneko Y, Sakakibara S, Imai T, et al. Musashi 1:an basement membrane. Trends Cell Biol. 2007; 17(1): 19-25 evolutionally conserved marker for CNS progenitor cells [33Kerever A, Schnack J, Vellinga D, et al. Novel extracellular including neural stem cells. Dev Neurosci. 2000; 2(1-2) natrix structures in the neural stem cell niche capture the 139-153 neurogenic factor fibroblast growth factor 2 from the [15 Wood HB, Episkopou V Comparative expression of the extracellular milieu. Stem Cells. 2007: 25(9) 2146-2157 mouse Sox1, Sox2 and Sox3 genes from pre-gastrulation [34] Nakagomi N, Nakagomi T, Kubo S, et al. Endothelial cells early somite stages. Mech Dev. 1999 86(1-2): 197-201 support survival, proliferation, and neuronal differentiation of [16 Kosodo Y, Roper K, Haubensak W, et al. Asymmetric transplanted adult ischemia-induced neural stem/progenitor distribution of the apical plasma membrane during neurogenic cells after cerebral infarction. Stem Cells. 2009 27(9): 185-2195 divisions of mammalian neuroepithelial cells. EMBO J. 2004: [35 Roitbak T, Li L, Cunningham LA Neural stem/progenitor cells 23(11)23142324 promote endothelial cell morphogenesis and protect [17 Ming GL, Song H Adult neurogenesis in the mammalian endothelial cells against ischemia via HIF-1alpha-regulatee central nervous system. Annu Rev Neurosci. 2005, 28: VEGF signaling. J Cereb Blood Flow Metab 2008, 28(9) 23-250. 530-1542 [18 Garcia AD, Doan NB, Imura T, et al. GFAP-expressing [36 Gomez-Gaviro MV, Scott CE, Sesay AK, et al. Betacellulin progenitors are the principal source of constitutive promotes cell proliferation in the neural stem cell niche and neurogenesis in adult mouse forebrain. Nat Neurosci. 2004 stimulates neurogenesis. Proc Natl Acad Sci U SA. 2012 7(11):1233-1241 109(4):1317-1322 [19 Kiss JZ, Muller D Contribution of the neural cell adhesion [37 Xu Q, Wang S, Jiang X, et al. Hypoxia-induced astrocytes molecule to neuronal and synaptic plasticity. Rev Neurosci promote the migration of neural progenitor cells via vascular 001;12(4)297-310. endothelial factor, stem cell factor, stromal-derived factor-1alpha [20 Kuegler PB, Zimmer B, Waldmann T, et al. Markers of murine and monocyte chemoattractant protein-1 upregulation in vitr embryonic and neural stem cells, neurons and astrocytes Clin Exp Pharmacol Physiol. 2007; 34(7): 624-631 reference points for developmental neurotoxicity testing [38 Lim DA, Alvarez-Buylla A Interaction between astrocytes and ALTEX 1742 adult subventricular zone precursors stimulates neurogenesis [21] Doetsch F, Garcia-Verdugo JM, Alvarez-Buylla A Cellular Proc Natl Acad SciU SA. 1999 96(13): 7526-753 composition and three-dimensional organization of the [39 Oh J, Recknor JB, Recknor JC, et al. Soluble factors from ubventricular germinal zone in the adult mammalian brain. J neocortical astrocytes enhance neuronal differentiation of Neurosci.1997;17(13)5046-5061. neural progenitor cells from adult rat hippocampus on [22] Doetsch F, Caille 1, Lim DA, et al. Subventricular zone micropatterned polymer substrates. J Biomed Mater Res A astrocytes are neural stem cells in the adult mammalian brain 2009,91(2):575-585 cel.199997(6):703-716. [40] Madhavan L, Daley BF, Paumier KL, et al. Transplantation of [23] Gage FH. Mammalian neural stem cells. Science. 2000; ubventricular zone neural precursors induces an (5457):1433-1438 endogenous precursor cell response in a rat model of [24] Alvarez-Buylla A, Lim DA For the long run: maintaining 09:515(1):102-115 germinal niches in the adult brain Neuron. 2004: 41 (5) [41] Jiao J, Chen DF. Induction of neurogenesis in 683-686. nonconventional neurogenic regions of the adult central [25] Ming GL, Song H Adult neurogenesis in the mammalian nervous system by niche astrocyte-produced signals. Stem central nervous system. Annu Rev Neurosci. 2005: 28 Cells.200826(5):1221-1230 223-250 42] Mirzadeh Z, Merkle FT, Soriano-Navarmo M, et al. Neural stem [26] Tropepe V, Coles BL, Chiasson BJ, et al. Retinal stem cells in cells confer unique pinwheel architecture to the ventricular the adult mammalian eye. Science. 2000; 287(5460) surface in neurogenic regions of the adult brain. Cell Stem cel.20083(3):265-278 [27 Johansson CB, Momma S, Clarke DL, et al. Identification of a [43] Carlen M, Meletis K, Goritz C, et al. Forebrain ependymal eural stem cell in the adult mammalian central nervous system.ce.199996(1):2534 astrocytes after stroke. Nat Neurosci. 2009: 12(3): 259-267 3544 Po.Box1200,Shenyang110004www.crter.org o1994-2013ChinaAcademicJournalElectronicPublishingHouse.Allrightsreservedhttp:/www.cnki.net吴凌峰，等. 成体神经干细胞与微环境 3544 P.O. Box 1200, Shenyang 110004 www.CRTER.org www.CRTER.org [9] Song X, Zhu CH, Doan C, et al. Germline stem cells anchored by adherens junctions in the Drosophila ovary niches. Science. 2002;296(5574):1855-1857. [10] Doetsch F. A niche for adult neural stem cells. Curr Opin Genet Dev. 2003;13(5):543-550. [11] Arai F, Hirao A, Suda T. Regulation of hematopoiesis and its interaction with stem cell niches. Int J Hematol. 2005; 2(5): 371-376. [12] Sakaguchi M, Imaizumi Y, Okano H. Expression and function of galectin-1 in adult neural stem cells. Cell Mol Life Sci. 2007; 64(10):1254-1258. [13] Lendahl U, Zimmerman LB, McKay RD. CNS stem cells express a new class of intermediate filament protein. Cell. 1990;60(4):585-595. [14] Kaneko Y, Sakakibara S, Imai T, et al. Musashi1: an evolutionally conserved marker for CNS progenitor cells including neural stem cells. Dev Neurosci. 2000; 2(1-2): 139-153. [15] Wood HB, Episkopou V. Comparative expression of the mouse Sox1, Sox2 and Sox3 genes from pre-gastrulation to early somite stages. Mech Dev. 1999;86(1-2):197-201. [16] Kosodo Y, Röper K, Haubensak W, et al. Asymmetric distribution of the apical plasma membrane during neurogenic divisions of mammalian neuroepithelial cells. EMBO J. 2004; 23(11):2314-2324. [17] Ming GL, Song H. Adult neurogenesis in the mammalian central nervous system. Annu Rev Neurosci. 2005;28: 223-250. [18] Garcia AD, Doan NB, Imura T, et al. GFAP-expressing progenitors are the principal source of constitutive neurogenesis in adult mouse forebrain. Nat Neurosci. 2004; 7(11):1233-1241. [19] Kiss JZ, Muller D. Contribution of the neural cell adhesion molecule to neuronal and synaptic plasticity. Rev Neurosci. 2001;12(4):297-310. [20] Kuegler PB, Zimmer B, Waldmann T, et al. Markers of murine embryonic and neural stem cells, neurons and astrocytes: reference points for developmental neurotoxicity testing. ALTEX. 2010;27(1):17-42. [21] Doetsch F, García-Verdugo JM, Alvarez-Buylla A. Cellular composition and three-dimensional organization of the subventricular germinal zone in the adult mammalian brain. J Neurosci. 1997;17(13):5046-5061. [22] Doetsch F, Caillé I, Lim DA, et al. Subventricular zone astrocytes are neural stem cells in the adult mammalian brain. Cell. 1999;97(6):703-716. [23] Gage FH. Mammalian neural stem cells. Science. 2000; 287 (5457):1433-1438. [24] Alvarez-Buylla A, Lim DA. For the long run: maintaining germinal niches in the adult brain. Neuron. 2004;41(5): 683-686. [25] Ming GL, Song H. Adult neurogenesis in the mammalian central nervous system. Annu Rev Neurosci. 2005;28: 223-250. [26] Tropepe V, Coles BL, Chiasson BJ, et al. Retinal stem cells in the adult mammalian eye. Science. 2000;287(5460): 2032-2036. [27] Johansson CB, Momma S, Clarke DL, et al. Identification of a neural stem cell in the adult mammalian central nervous system. Cell. 1999;96(1):25-34. [28] Tavazoie M, Van der Veken L, Silva-Vargas V, et al. A specialized vascular niche for adult neural stem cells. Cell Stem Cell. 2008;3(3):279-288. [29] Shen Q, Wang Y, Kokovay E, et al. Adult SVZ stem cells lie in a vascular niche: a quantitative analysis of niche cell-cell interactions. Cell Stem Cell. 2008;3(3):289-300. [30] Teng H, Zhang ZG, Wang L, et al. Coupling of angiogenesis and neurogenesis in cultured endothelial cells and neural progenitor cells after stroke. J Cereb Blood Flow Metab. 2008; 28(4):764-771. [31] Shen Q, Goderie SK, Jin L, et al. Endothelial cells stimulate self-renewal and expand neurogenesis of neural stem cells. Science. 2004;304(5675):1338-1340. [32] Nikolova G, Strilic B, Lammert E. The vascular niche and its basement membrane. Trends Cell Biol. 2007;17(1):19-25. [33] Kerever A, Schnack J, Vellinga D, et al. Novel extracellular matrix structures in the neural stem cell niche capture the neurogenic factor fibroblast growth factor 2 from the extracellular milieu. Stem Cells. 2007;25(9):2146-2157. [34] Nakagomi N, Nakagomi T, Kubo S, et al. Endothelial cells support survival, proliferation, and neuronal differentiation of transplanted adult ischemia-induced neural stem/progenitor cells after cerebral infarction. Stem Cells. 2009;27(9):185-2195. [35] Roitbak T, Li L, Cunningham LA. Neural stem/progenitor cells promote endothelial cell morphogenesis and protect endothelial cells against ischemia via HIF-1alpha-regulated VEGF signaling. J Cereb Blood Flow Metab. 2008;28(9): 530-1542. [36] Gómez-Gaviro MV, Scott CE, Sesay AK, et al. Betacellulin promotes cell proliferation in the neural stem cell niche and stimulates neurogenesis. Proc Natl Acad Sci U S A. 2012; 109(4):1317-1322. [37] Xu Q, Wang S, Jiang X, et al. Hypoxia-induced astrocytes promote the migration of neural progenitor cells via vascular endothelial factor, stem cell factor, stromal-derived factor-1alpha and monocyte chemoattractant protein-1 upregulation in vitro. Clin Exp Pharmacol Physiol. 2007;34(7):624-631. [38] Lim DA, Alvarez-Buylla A. Interaction between astrocytes and adult subventricular zone precursors stimulates neurogenesis. Proc Natl Acad Sci U S A. 1999;96(13):7526-7531. [39] Oh J, Recknor JB, Recknor JC, et al. Soluble factors from neocortical astrocytes enhance neuronal differentiation of neural progenitor cells from adult rat hippocampus on micropatterned polymer substrates. J Biomed Mater Res A. 2009;91(2):575-585. [40] Madhavan L, Daley BF, Paumier KL, et al. Transplantation of subventricular zone neural precursors induces an endogenous precursor cell response in a rat model of Parkinson's disease. J Comp Neurol. 2009;515(1):102-115. [41] Jiao J, Chen DF. Induction of neurogenesis in nonconventional neurogenic regions of the adult central nervous system by niche astrocyte-produced signals. Stem Cells. 2008;26(5):1221-1230. [42] Mirzadeh Z, Merkle FT, Soriano-Navarro M, et al. Neural stem cells confer unique pinwheel architecture to the ventricular surface in neurogenic regions of the adult brain. Cell Stem Cell. 2008;3(3):265-278. [43] Carlén M, Meletis K, Göritz C, et al. Forebrain ependymal cells are Notch-dependent and generate neuroblasts and astrocytes after stroke. Nat Neurosci. 2009;12(3):259-267