1)Increase in 2)Increase in intergenic sequences 3)Increase in the intron sequences 4) Increase in ge wide rep 5)Increase in the telomere sequence and complexity 5. The chromosome element important for chromosome segregation 1)Telomere 2)Centro 4)Replication fork 6. Which of the following persons won the Nobel prize because of his/her contribution in discovery of transposable element? 1)Barbara McClintock 2)Joan Steitz 3)Francis Crick 4)Philip Sharp 7. Which of the following mechanisms is not related to Dna damage repair? 1)B 2) Nucleotide excision repair 3)Translesion repair 4)Mismatch repair 5)Double-stand break repair pathway 9. Which of the following statements for translation is NOT CORRECT? 1) Ribosome contains both the decoding center and peptidyl transferase center 2) The peptidyl transferase activity is resided in the large ribosomal RNA 3) Ribosome can directly interpret the genetic information on the mRNa into the corresponding amino acids sequence 4) Peptide bond formation and EF-G drive translocation of the tRNa and the mrNa 10. Which of the following statements on homologous replication is NOT CORRECT? 1)Holliday model illustrates key steps in homologous recombination 2)Homologous recombination is often initiated by double-stranded breaks in DNA It is known that Spol l generates double-stranded breaks in eukaryote 3) RecBCd helicase/nuclease processes broken DNa molecules and generates a single-stranded end 4)Ruv aB complex and Dmcl specifically promotes branch migration in bacteria and eukaryotes, respectively PART III: SHORT QUESTIONS (CHOOSE FIVE QUESTIONS TO ANSWER) (6 points each) 1. What is the central dogma? 2.C he chemistry and mechanism of splicing of the common pre-mRNA introns and group I and group II introns 3. Briefly describe or illustrate how an extracellular signal can alter intracellular gene expre1) Increase in gene size 2) Increase in intergenic sequences 3) Increase in the intron sequences 4) Increase in genome-wide repeat sequence 5) Increase in the telomere sequence and complexity 5. The chromosome element important for chromosome segregation is 1) Telomere 2) Centromere 3) Origin of replication 4) Replication fork 6. Which of the following persons won the Nobel prize because of his/her contribution in discovery of transposable element? 1) Barbara McClintock 2) Joan Steitz 3) Francis Crick 4) Philip Sharp 7. Which of the following mechanisms is not related to DNA damage repair? 1) Base excision repair 2) Nucleotide excision repair 3) Translesion repair 4) Mismatch repair 5) Double-stand break repair pathway 9. Which of the following statements for translation is NOT CORRECT? 1) Ribosome contains both the decoding center and peptidyl transferase center 2) The peptidyl transferase activity is resided in the large ribosomal RNA 3) Ribosome can directly interpret the genetic information on the mRNA into the corresponding amino acids sequence 4) Peptide bond formation and EF-G drive translocation of the tRNA and the mRNA 10. Which of the following statements on homologous replication is NOT CORRECT? 1) Holliday model illustrates key steps in homologous recombination 2) Homologous recombination is often initiated by double-stranded breaks in DNA. It is known that Spo11 generates double-stranded breaks in eukaryote. 3) RecBCD helicase/nuclease processes broken DNA molecules and generates a single-stranded end. 4) RuvAB complex and Dmc1 specifically promotes branch migration in bacteria and eukaryotes, respectively. PART III: SHORT QUESTIONS (CHOOSE FIVE QUESTIONS TO ANSWER) (6 points each) 1. What is the central dogma? 2. Compare the chemistry and mechanism of splicing of the common pre-mRNA introns and group I and group II introns. 3. Briefly describe or illustrate how an extracellular signal can alter intracellular gene expression