Size of the metabolic cores s Metabolic cores in different organisms H pylori: 36.2%o E. coli: 11.90o S cerevisiae: 2.8%0 ■ Explanation Little flexibility for biomass production in H pylori 61°0 of the e pylori reactions are active on average Higher metabolic flexibility in E. coli and S. cerevisiae On average, 35.3%o and 19.7%o of the reactions are required in E. coli and s cerevisiae,respectively. Alternative pathways: 20 out of the 51 biomass constituents in E coli are not produced by the core The more reactions a metabolic network possesses, the stronger is the network-induced redundancy, and the smaller is the coreSize of the metabolic cores ◼ Metabolic cores in different organisms: ◼ H. pylori: 36.2% ◼ E. coli: 11.9% ◼ S. cerevisiae: 2.8% ◼ Explanation ◼ Little flexibility for biomass production in H. pylori ◼ 61% of the H. pylori reactions are active on average. ◼ Higher metabolic flexibility in E. coli and S. cerevisiae ◼ On average, 35.3% and 19.7% of the reactions are required in E. coli and S. cerevisiae, respectively. ◼ Alternative pathways: 20 out of the 51 biomass constituents in E. coli are not produced by the core. ◼ The more reactions a metabolic network possesses, the stronger is the network-induced redundancy, and the smaller is the core