Thr NEW ENGLAND JOURNAL f MEDICINE 8001005606 0'Et-o)OZt 477000m 昌目日目 0901000 6t-PiNoD ()ou-uopenuapa (%ou-unsuu!o1 10 N ENGLJ MED NEJM.ORO10 n engl j med nejm.org The new england journal o f medicine Table 3. Complications, Treatments, and Clinical Outcomes. Variable All Patients (N=1099) Disease Severity Presence of Composite Primary End Point Nonsevere (N=926) Severe (N=173) Yes (N=67) No (N=1032) Complications Septic shock — no. (%) 12 (1.1) 1 (0.1) 11 (6.4) 9 (13.4) 3 (0.3) Acute respiratory distress syndrome — no. (%) 37 (3.4) 10 (1.1) 27 (15.6) 27 (40.3) 10 (1.0) Acute kidney injury — no. (%) 6 (0.5) 1 (0.1) 5 (2.9) 4 (6.0) 2 (0.2) Disseminated intravascular coagulation — no. (%) 1 (0.1) 0 1 (0.6) 1 (1.5) 0 Rhabdomyolysis — no. (%) 2 (0.2) 2 (0.2) 0 0 2 (0.2) Physician-diagnosed pneumonia — no./total no. (%) 972/1067 (91.1) 800/894 (89.5) 172/173 (99.4) 63/66 (95.5) 909/1001 (90.8) Median time until development of pneumonia (IQR) — days* After initial Covid-19 diagnosis 0.0 (0.0–1.0) 0.0 (0.0–1.0) 0.0 (0.0–2.0) 0.0 (0.0–3.5) 0.0 (0.0–1.0) After onset of Covid-19 symptoms 3.0 (1.0–6.0) 3.0 (1.0–6.0) 5.0 (2.0–7.0) 4.0 (0.0–7.0) 3.0 (1.0–6.0) Treatments Intravenous antibiotics — no. (%) 637 (58.0) 498 (53.8) 139 (80.3) 60 (89.6) 577 (55.9) Oseltamivir — no. (%) 393 (35.8) 313 (33.8) 80 (46.2) 36 (53.7) 357 (34.6) Antifungal medication — no. (%) 31 (2.8) 18 (1.9) 13 (7.5) 8 (11.9) 23 (2.2) Systemic glucocorticoids — no. (%) 204 (18.6) 127 (13.7) 77 (44.5) 35 (52.2) 169 (16.4) Oxygen therapy — no. (%) 454 (41.3) 331 (35.7) 123 (71.1) 59 (88.1) 395 (38.3) Mechanical ventilation — no. (%) 67 (6.1) 0 67 (38.7) 40 (59.7) 27 (2.6) Invasive 25 (2.3) 0 25 (14.5) 25 (37.3) 0 Noninvasive 56 (5.1) 0 56 (32.4) 29 (43.3) 27 (2.6) Use of extracorporeal membrane oxygenation — no. (%) 5 (0.5) 0 5 (2.9) 5 (7.5) 0 Use of continuous renal-replacement therapy — no. (%) 9 (0.8) 0 9 (5.2) 8 (11.9) 1 (0.1) Use of intravenous immune globulin — no. (%) 144 (13.1) 86 (9.3) 58 (33.5) 27 (40.3) 117 (11.3) Admission to intensive care unit — no. (%) 55 (5.0) 22 (2.4) 33 (19.1) 55 (82.1) 0 Median length of hospital stay (IQR) — days† 12.0 (10.0–14.0) 11.0 10.0–13.0) 13.0 (11.5–17.0) 14.5 (11.0–19.0) 12.0 (10.0–13.0) The New England Journal of Medicine Downloaded from nejm.org at SOUTHERN MEDICAL UNIVERSITY on March 6, 2020. For personal use only. No other uses without permission. Copyright © 2020 Massachusetts Medical Society. All rights reserved