Example: -Skin cooling(Hand immersed in the ice water) Central T↓ Sensors Sympathetic Norepine phrine NE t nerves Membrane Local Receptors t Vascontraction Muscle NE transmission relaxation receptor activity. MetabolismlT BF Less heat loss Activate NE Vasodilation BF↑ T↑ receptors BF↓Example: – Skin cooling (Hand immersed in the ice water) Metabolism Sympathetic nerves Norepine phrine NE Membrane Receptors BF NE transmission receptor activity Muscle relaxation Vasodilation BF T Activate NE receptors BF T T Sensors Local Central Vascontraction Less heat loss