5-HTIF Agonists:Lasmiditan Selective inverse 5-HT2A agonist:pimavanserin 5-HT2B agonist:fenfluramine/phentermine 5-HT2C agonist:lorcaserin 5-HT2C antagonist:Agomelatine 5-HT-3 Receptor Antagonists:Ondansetron Section 3 Drugs affecting central nervous system 3.1教学目标 Get a general idea about Parkinson'diseases,Get a general idea about dopamine and its functions and neurochemistry,and the distribution,structures and functions of dopamine receptor. Understand the development history of antiparkinsonian drugs. To master the chemical structures,drug design,structure-activity relationships,and mechanism of actions of major antiparkinsonian drugs;Understand the synthesis and metabolism of antiparkinsonian drugs 3.2教学重难点 Drug discovery and design,chemical structures,structure-activity relationships,and mechanism of actions of major drugs affecting central nervous system 3.3.教学内容 3.3.1Drugs Used to Treat Neuromuscular Disorders:Antiparkinsonian Agents Including the following specific drugs: Dopamine replacement:L-DOPA,carbidopa,Tolcapone,Selegiline,Rasagiline;Safinamide Dopamine Receptor Agonists:apomorphine,pramipexole,ropinirole Drugs Indirectly Target Dopamine System:Amantadine,Artane,Rivastigmine,Istradefylline 3.3.2 Antipsychotic Drugs Get a general idea about Mental illnesses.5-HT1F Agonists: Lasmiditan Selective inverse 5-HT2A agonist: pimavanserin 5-HT2B agonist: fenfluramine/phentermine 5-HT2C agonist: lorcaserin 5-HT2C antagonist: Agomelatine 5-HT-3 Receptor Antagonists: Ondansetron Section 3 Drugs affecting central nervous system 3.1 教学目标 Get a general idea about Parkinson’diseases, Get a general idea about dopamine and its functions and neurochemistry, and the distribution, structures and functions of dopamine receptor. Understand the development history of antiparkinsonian drugs. To master the chemical structures, drug design, structure-activity relationships, and mechanism of actions of major antiparkinsonian drugs; Understand the synthesis and metabolism of antiparkinsonian drugs. 3.2 教学重难点 Drug discovery and design, chemical structures, structure-activity relationships, and mechanism of actions of major drugs affecting central nervous system 3.3.教学内容 3.3.1Drugs Used to Treat Neuromuscular Disorders: Antiparkinsonian Agents Including the following specific drugs: Dopamine replacement: L-DOPA, carbidopa, Tolcapone, Selegiline,Rasagiline; Safinamide Dopamine Receptor Agonists: apomorphine, pramipexole, ropinirole Drugs Indirectly Target Dopamine System: Amantadine, Artane, Rivastigmine, Istradefylline 3.3.2 Antipsychotic Drugs Get a general idea about Mental illnesses