The acid chloride to ester transformation is standard nucleophilic acyl substitution. R C -C一O-R'+HCI ester Ammonia and amines react with acid chlorides to give amides,also through this addition-elimination version of nucleophilic acyl substitution. Eg 0 2R'-NH2 O R-C-CI →R-C-NHR'+RNH3CI Ch20 Carboxylic Acids (landscape) Page 25Ch20 Carboxylic Acids (landscape) Page 25 The acid chloride to ester transformation is standard nucleophilic acyl substitution. Ammonia and amines react with acid chlorides to give amides, also through this addition-elimination version of nucleophilic acyl substitution. E.g. R C O Cl R C O NHR' 2 R'-NH2 + R'NH3 +-Cl