[12]Haig D.Intragenomic politics.Cytogenet Genome Res,2006,113(1-4):68-74. [13]张丹，徐谷峰，黄荷凤.辅助生殖技术与基因印迹异常.国际生殖健康/计划生育杂 志，2011，(04)：282-286 [14]Junien C.Beckwith-Wiedemann syndrome,tumourigenesis and imprinting.Curr Opin Genet Dev,.1992,2(3):431-438. [15]Van der Auweta L D Hooghe T.Superovulation of female mice delays embryonic and fetal development,Hum Repord,2001,16(6):1237-1243. [16]Shi W.Haaf T.Aberrant methylation pattems at the two-cell stage as an indicator of early developmental failure.Mol Reprod Dev,2002,63(3):329-334. [17]Khosla S,Dean W,Brown D,et al.Culture of preimplantation mouse embroys affects fetal development and the expression of imprinted genes.Biol reprod,2001,64(3):918-926. [18]Weksberg R,Shuman C,Smith AC.Beckwith-Wiedemann syndrome.Am J Med Genet C Semin Med Genet,2005,137C(1):12-23. [19]Berland,Siren;Appelbaeck,Mia;Bruland,Ove;Beygo,Jasmin;Buiting,Karin;Mackay, DeborahJ.G.;Temple,I.Karen;Houge,Gunnar.Evidenceforanticipationin Beckwith-Wiedena bb syndrome.European Journal of Human Genetics,2013,21(12):1344-1348. [20]Oyce JA et al Hum Mo I Genet,1997,6:1543-1548. [21山张颖莹（综述），史惠蓉（审校），孔祥东（审校）.基因组印迹与辅助生殖[J].国 外医学：计划生育.生殖健康分册，2006,25(5)：247-249. [22]HallidayJ,OkeK,Breheny S,et al.Beckwith-Wiedemann syndrome and IVF:a case-control study.Am J Hum Genet,2004,75(3):526-528. [23]Radstaake,Maartje Didden,Robert,Giesbers,Sanne;Korzilius,Hubert,Peters-Scheffer, Nienke,Lang,Russell,vonGontard,Alexander;Curfs,LeopoldM.G.Research in Developmental Disabilities,.2013,34(11):4184-4193. [24]Kishino T,Lalande M,Wagstaff J.UBE3A/E6-AP mutations cause Angelman syndrome. Nat Genet,1997,15(1)70-73. [25]Clayton-Smith J,Laan L.Angelman syndrome:a review of the clinical and genetic aspects.J Med Genet,2003,40(2):87-95. [26]Ludwig M KA,Gross S SA,Varon R HB.Increased prevalence of imprinting defects in patients with Angelman syndrome born to subfertile couples.J Med Genet,2005,42(4): 289-291. [27]Sutcliffe APCJ,BowdinS ea.Assisted reproductive therapies and imprinting disorders-a preliminary British survey.Hum Reprod,2006,21(4):1009-1011. [28]Doornbos ME MSM,McDonnell J VJP,Hennekam RC.Infertility,assisted reproduction technologies and imprinting disturbances:a Dutch study.Human Reproduction,2007,22: 2476-2480. [29]Amor DJ,Halliday J.A review of known imprinting syndromes and their association with assisted reproduction technologies.Hum Reprod,2008,23(12):2826-34. [30]郝丽君，崔英霞.Silver-Russell综合征研究进展.中国优生与遗传杂志，2006，(04)： 122-123. [31]Blaise,A.CDKNIC mutation affecting the PCNA-binding domain as a cause of familial Russell silver syndrome.Journal of Medical Genetics,2013,50(12):823-830. [32]Abu-Amero S,Wakeling EL,Preece M,Whittaker J,Stanier P,Moore GE.Epigenetic signatures of Silver-Russel syndrome.J Med Genet,2010,47(3):150-4. [33]Kagami M,Nagai T,Fukami M,Yamazawa K,Ogata T.Silver-Russell syndrome in a girl born after in vitro fertilization:partial hypermethylation at the differentially methylated region of PEG1/MEST.J Assist Reprod Genet,2007,24(4):131-6.[12]Haig D. Intragenomic politics. Cytogenet Genome Res,2006,113(1-4):68-74. [13]张丹, 徐谷峰, 黄荷凤. 辅助生殖技术与基因印迹异常. 国际生殖健康/计划生育杂 志, 2011, (04):282-286. [14]Junien C. Beckwith-Wiedemann syndrome, tumourigenesis and imprinting. Curr Opin Genet Dev,1992, 2(3):431-438. [15]Van der Auweta L D Hooghe T.Superovulation of female mice delays embryonic and fetal development,Hum Repord,2001,16(6):1237-1243. [16]Shi W.Haaf T.Aberrant methylation pattems at the two-cell stage as an indicator of early developmental failure.Mol Reprod Dev,2002,63(3):329-334. [17]Khosla S,Dean W,Brown D,et al.Culture of preimplantation mouse embroys affects fetal development and the expression of imprinted genes.Biol reprod,2001,64(3):918-926. [18]Weksberg R, Shuman C, Smith AC. Beckwith-Wiedemann syndrome. Am J Med Genet C Semin Med Genet, 2005,137C(1):12-23. [19]Berland, Siren; Appelbaeck, Mia; Bruland, Ove; Beygo, Jasmin; Buiting, Karin; Mackay, DeborahJ.G.; Temple,I.Karen; Houge,Gunnar.Evidenceforanticipationin Beckwith-Wiedena bb syndrome.European Journal of Human Genetics ,2013,21(12):1344-1348. [20]Oyce JA et al .Hum Mo l Genet,1997,6:1543-1548. [21]张颖莹（综述）,史惠蓉（审校）,孔祥东（审校）.基因组印迹与辅助生殖[J].国 外医学：计划生育．生殖健康分册,2006,25(5):247-249. [22]HallidayJ,OkeK,Breheny S, et al.Beckwith-Wiedemann syndrome and IVF:a case-control study.Am J Hum Genet,2004,75(3):526-528. [23] Radstaake, Maartje Didden, Robert,Giesbers, Sanne; Korzilius, Hubert,Peters-Scheffer, Nienke,Lang,Russell,vonGontard,Alexander; Curfs,LeopoldM.G.Research in Developmental Disabilities,2013,34(11):4184-4193. [24]Kishino T, Lalande M, Wagstaff J. UBE3A/E6-AP mutations cause Angelman syndrome. Nat Genet, 1997, 15(1):70-73. [25]Clayton-Smith J, Laan L. Angelman syndrome: a review of the clinical and genetic aspects. J Med Genet,2003, 40(2):87-95. [26]Ludwig M KA, Gross S SA, Varon R HB. Increased prevalence of imprinting defects in patients with Angelman syndrome born to subfertile couples. J Med Genet,2005,42(4): 289–291. [27]Sutcliffe APCJ,BowdinS ea.Assisted reproductive therapies and imprinting disorders—a preliminary British survey. Hum Reprod,2006,21(4):1009–1011. [28]Doornbos ME MSM, McDonnell J VJP, Hennekam RC. Infertility, assisted reproduction technologies and imprinting disturbances: a Dutch study.Human Reproduction,2007,22: 2476–2480. [29]Amor DJ, Halliday J. A review of known imprinting syndromes and their association with assisted reproduction technologies. Hum Reprod,2008,23(12):2826-34. [30]郝丽君, 崔英霞. Silver-Russell 综合征研究进展. 中国优生与遗传杂志,2006,(04): 122-123. [31]Blaise,A.CDKN1C mutation affecting the PCNA-binding domain as a cause of familial Russell silver syndrome. Journal of Medical Genetics ,2013,50(12):823-830. [32]Abu-Amero S, Wakeling EL, Preece M, Whittaker J, Stanier P, Moore GE. Epigenetic signatures of Silver-Russel syndrome. J Med Genet,2010,47(3):150-4. [33]Kagami M, Nagai T, Fukami M, Yamazawa K, Ogata T. Silver-Russell syndrome in a girl born after in vitro fertilization: partial hypermethylation at the differentially methylated region of PEG1/MEST. J Assist Reprod Genet,2007,24(4):131-6