stimulus response. To enhance the immune response, we selected cordycepin as a potential adjuvant of the hepatitis B vaccine. The results of our experiments showed that cordycepin significantly enhances humoral and cellular immunity in balB/c mice without any side effects. Our results lay the foundation for the investigation of new combined vaccines Method Dataset construction. All the ingredients of Ophiocordyceps sinensis were extracted from the Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform(http://sp.nwsuafedu.cn/tcmsp.php)andtheAnticancerHerbsDatabaseof SystemsPharmacology(http://sp.nwsuaf.edu.cn/cancerhspphp).Twentypotential compounds with OB 2 30%, DL 20.18 or HL 4 were selected. Additionally, three compounds in the CancerHSP Database with potential anti-cancer activities and ob> 30% were also selected as candidate compounds for further analysis. Duplicate compounds in the two databases were eliminated, yielding 23 readily-absorbed ds from a total pounds. After eliminating the additional compounds without targets, the 190 targets in the database were assembled and ranked for the 17 Its present in O. siner Network construction. To obtain a better understanding of the complex relationship between the compounds and targets, a network was constructed. The candidate compounds and potential targets were used to construct the compound-target network The network was generated and analyzed by Cytoscape 3. 2. 1. The degree of a node12 stimulus response. To enhance the immune response, we selected cordycepin as a potential adjuvant of the hepatitis B vaccine. The results of our experiments showed that cordycepin significantly enhances humoral and cellular immunity in BALB/c mice without any side effects. Our results lay the foundation for the investigation of new combined vaccines. Methods Dataset construction. All the ingredients of Ophiocordyceps sinensis were extracted from the Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform (http://lsp.nwsuaf.edu.cn/tcmsp.php) and the Anticancer Herbs Database of Systems Pharmacology (http://lsp.nwsuaf.edu.cn/CancerHSP.php). Twenty potential compounds with OB ≥ 30%, DL ≥ 0.18 or HL ≥ 4 were selected. Additionally, three compounds in the CancerHSP Database with potential anti-cancer activities and OB ≥ 30% were also selected as candidate compounds for further analysis. Duplicate compounds in the two databases were eliminated, yielding 23 readily-absorbed compounds from a total of 40 compounds. After eliminating the additional compounds without targets, the 190 targets in the database were assembled and ranked for the 17 components present in O. sinensis. Network construction. To obtain a better understanding of the complex relationships between the compounds and targets, a network was constructed. The candidate compounds and potential targets were used to construct the compound-target network. The network was generated and analyzed by Cytoscape 3.2.170. The degree of a node