Overview of the experiment In this experiment, students will be introduced to several uses of the computer and the Internet. Students are instructed in the use of bibliographic searches, sequence databases, and structural analytical tools available, free of charge, on the web Table E1.3 Useful programs for exploring structures/sequences rogram Function BLAST Searches for similar protein and nuclei acid sequences Chime Protein structures on moving 3D Entrez(NcBi) Sequence retrieval system cross-referencing databases FASTA Searches for similar protein sequences Gen Bank(NCBi) Databases of gene sequences Molecules r us Provides coordinates for protein 3D structure and manipulation RasMol(ras mac) Provides coordinates for protein 3D structure and manipulation SRS(EMBL) Sequence retrieval vste cross-referencing databases I. Materials and supplies Computer: Apple Macintosh or PC with printer; connected to the Internet Software: Web browser such as Netscape navigator or Internet explorer; e-mail program such as Eudora. II. Experimental procedure 1. Searching the biochemical literature on medline To illustrate the use of this search service, point your Web browser to the appropriate Url(Http://www.nim.nihgov/ThiswillconnectyoutotheNationalCenterfor Biotechnology Information. Click the mouse on the hyperlink"PubMed". Select MEDLINE302 Overview of the experiment In this experiment, students will be introduced to several uses of the computer and the Internet. Students are instructed in the use of bibliographic searches, sequence databases, and structural analytical tools available, free of charge, on the Web. Table E1.3 Useful programs for exploring structures/sequences Program Function BLAST Searches for similar protein and nucleic acid sequences Chime Protein structures on moving 3D coordinates Entrez(NCBI) Sequence retrieval system for cross-referencing databases FASTA Searches for similar protein sequences GenBank(NCBI) Databases of gene sequences Molecules R Us Provides coordinates for protein 3D structure and manipulation RasMol(Ras Mac) Provides coordinates for protein 3D structure and manipulation SRS(EMBL) Sequence retrieval system for cross-referencing databases Ⅱ. Materials and supplies Computer: Apple Macintosh or PC with printer; connected to the Internet. Software: Web browser such as Netscape Navigator or Internet Explorer; e-mail program such as Eudora. Ⅲ. Experimental procedure 1. Searching the biochemical literature on MEDLINE To illustrate the use of this search service, point your Web browser to the appropriate URL(http://www.nlm.nih.gov/) This will connect you to the National Center for Biotechnology Information. Click the mouse on the hyperlink “PubMed”. Select MEDLINE