Chapter 6 Exploring Evolution and Bioinformatics w 6 Analysis of substitution matrices indicates that cysteine(C)and residues tend to be conserved more than other amino acid residues. Ans:tryptophan (W)Section:6.2 7 The process by which very different evolutionary pathways lead to a protein with similar function is referred to as evolution. Ans:convergent Section:6.3 8 Repeated motifs,or domains,can be detected in proteins by aligning sequences with Ans:themselves Section:6.3 9 A conservative substitution of a lysine(K)residue would be replacement with a/an residue. Ans:arginine(R)Section:6.2 10 Comparison of three-dimensional structures indicated that heat shock protein 70 is a paralog of despite only 15.6%sequence identity. Ans:actin Section:6.3 Multiple Choice Questions 1 Protein sequence comparisons can provide estimates of A) protein function. D All of the above B) protein shape. E) b and c only C) pathways of evolutionary descent. Ans:E Section:Introduction 2 The definition of a homolog is A) molecules related by sequence similarity. B) two molecules derived from a common ancestral protein. C) molecules with similar domains. D) All of the above. E) None of the above. Ans:B Section:6.1 3 Paralogs differ in A)detailed biochemical functions. D) All of the above. B) ancestral evolution. E) None of the above. C)ornithology. Ans:A Section:6.1 4 An example of a conservative substitution would be A)Ala to Trp D) All of the above B)Gly to Ser. E) None of the above. C)Asp to Glu. Ans:C Section:6.2Chapter 6 Exploring Evolution and Bioinformatics 3 6 Analysis of substitution matrices indicates that cysteine (C) and __________________ residues tend to be conserved more than other amino acid residues. Ans: tryptophan (W) Section: 6.2 7 The process by which very different evolutionary pathways lead to a protein with similar function is referred to as _________________ evolution. Ans: convergent Section: 6.3 8 Repeated motifs, or domains, can be detected in proteins by aligning sequences with __________________. Ans: themselves Section: 6.3 9 A conservative substitution of a lysine (K) residue would be replacement with a/an ____________ residue. Ans: arginine (R) Section: 6.2 10 Comparison of three-dimensional structures indicated that heat shock protein 70 is a paralog of ____________, despite only 15.6% sequence identity. Ans: actin Section: 6.3 Multiple Choice Questions 1 Protein sequence comparisons can provide estimates of A) protein function. D) All of the above B) protein shape. E) b and c only C) pathways of evolutionary descent. Ans: E Section: Introduction 2 The definition of a homolog is A) molecules related by sequence similarity. B) two molecules derived from a common ancestral protein. C) molecules with similar domains. D) All of the above. E) None of the above. Ans: B Section: 6.1 3 Paralogs differ in A) detailed biochemical functions. D) All of the above. B) ancestral evolution. E) None of the above. C) ornithology. Ans: A Section: 6.1 4 An example of a conservative substitution would be A) Ala to Trp. D) All of the above. B) Gly to Ser. E) None of the above. C) Asp to Glu. Ans: C Section: 6.2