Predisposing Psycho Concurrent Brain-gut factors Physiological modifiers dysregulation triggers Chronic threat prolonged effortful coping early e 个 Enteric Genetic Environment Infection nflammation toxinsPredisposing factors Psycho￾Physiological triggers Concurrent modifiers Brain-gut dysregulation Early life Genetic Environment Chronic threat & prolonged effortful coping Enteric Infection/ Inflammation/ toxins ↑↓