5.1.教学目标 Leamn the drugs used to diabetes and osteoporosis. Get a general idea of how biological (protein)drugs have very different considerations compared to small molecule drugs. 5.2.教学重难点 The development of meal-time and long-acting insulin is based on the aggregation states of human insulin. The advantage of GLP-1 analogs over insulin,and their highly competitive history of development. DPP-4 inhibitors can have very different pharmacophores. Metformin's structure is related to its major side effect. How the second generation of sulfonylureas greatly reduced the side effects Bisphosphonates'pharmacophore is directly related to their unique PK properties and mechanism of action,while individual drugs structure leads to less dosing frequency and improved side effects. 5.3.教学内容 (1)Drugs used to treat diabetes Insulin GLP-1 analogs Oral hyperglycemic agents,including:Biguanides;Insulin secretagogues;Insulin sensitizers,a-glucosidase inhibitors;DPP-IV inhibitors;Amylin antagonists;SGLT2 inhibitors (2)Drugs used to treat osteoporosis Anti-resorptive agents:Estrogen analogs;Selective estrogen receptor modulators;Bisphosphonates;and Calcitonin Bone-forming agents:Forteo and Inorganic salts5.1.教学目标 Learn the drugs used to diabetes and osteoporosis. Get a general idea of how biological (protein) drugs have very different considerations compared to small molecule drugs. 5.2.教学重难点 The development of meal-time and long-acting insulin is based on the aggregation states of human insulin. The advantage of GLP-1 analogs over insulin, and their highly competitive history of development. DPP-4 inhibitors can have very different pharmacophores. Metformin's structure is related to its major side effect. How the second generation of sulfonylureas greatly reduced the side effects. Bisphosphonates' pharmacophore is directly related to their unique PK properties and mechanism of action, while individual drugs structure leads to less dosing frequency and improved side effects. 5.3.教学内容 (1) Drugs used to treat diabetes Insulin GLP-1 analogs Oral hyperglycemic agents, including: Biguanides; Insulin secretagogues; Insulin sensitizers; α-glucosidase inhibitors; DPP-IV inhibitors; Amylin antagonists; SGLT2 inhibitors (2) Drugs used to treat osteoporosis Anti-resorptive agents: Estrogen analogs; Selective estrogen receptor modulators; Bisphosphonates; and Calcitonin Bone-forming agents: Forteo and Inorganic salts