CONTENTS Introduction to medicinal chemistry...... General priciples of drug action.. 234567 ical properties of organic medicinl agents. es 2 Sedative-h Pav Antiepileptic 102 Cholinergic and anticholinergic drugs 121 11. Adrenergic drugs .149 12. Adrenoreceptor blocking drugs .170 13. Skeletal muscle relaxants.. 180 14. Antihistamines 184 Narcotic analgesics 211 Narcotic antagonists .... 225 Antitussives 229 Non-steroidal antiinflammatory drugs 181902 232 Local anesthetics Diuretics. 器 ce Ques 315 317C-8—N-CHEMI\TITLE.PM5 4   1. Introduction to medicinal chemistry ........................................................................... 1 2. General priciples of drug action ................................................................................... 3 3. Physico chemical properties of organic medicinal agents ........................................ 14 4. Chemistry of prodrugs ................................................................................................ 31 5. Drug metabolism......................................................................................................... 41 6. General anesthetics .................................................................................................... 52 7. Sedative-hypnotic drugs ............................................................................................. 61 8. Psychoactive drugs...................................................................................................... 77 9. Antiepileptic agents .................................................................................................. 102 10. Cholinergic and anticholinergic drugs .................................................................... 121 11. Adrenergic drugs ....................................................................................................... 149 12. Adrenoreceptor blocking drugs ................................................................................ 170 13. Skeletal muscle relaxants ........................................................................................ 180 14. Antihistamines .......................................................................................................... 184 15. Narcotic analgesics ................................................................................................... 211 16. Narcotic antagonists ................................................................................................. 225 17. Antitussives ............................................................................................................... 229 18. Non-steroidal antiinflammatory drugs ................................................................... 232 19. Local anesthetics ....................................................................................................... 249 20. Diuretics .................................................................................................................... 259 21. Hypoglycemic agents ................................................................................................ 270 22. Thyroid and antithyroid drugs ................................................................................. 282 Practice Questions ..................................................................................................... 290 References .................................................................................................................. 315 Index .......................................................................................................................... 317