国际眼科杂志207年10月第1卷第10期htp:/ls.j.cn 电话:029-82245172 263940电子信箱:Uo.2000@163.com 量来证实其在CNV临床检测应用中更好的灵敏度及特14 Karadimas p, Bouzas ea. Fundus autofluorescence inaging in sero 异性。 and drusenoid pigment epithelial detachments associated with age-related 5小结 macular degeneration. Am J Opthalmol 2005: 140(6): 1163-1165 综上所述,眼科影像学检查在近年来取得了很大进5懿,赵培泉,彭清年龄相关性黄斑变性患者眼底玻璃膜疣的自 展,目前已广泛应用于AMD的临床诊断,并且为疾病的发荧光特征中华眼科杂志2010;46(9):708-713 16 Bindewald A. Bird AC. Dandekar SS, ef al. Classification of fundus 发病机制、疗效评价及预后判断提供可靠依据。未来应 related macular disease 该将影像技术与数码技术进一步结合,在对AMD定性 Ophthalmol Vis s20046(9):30-314 分析的基础上进行定量分析,可能更具临床和研究17 Hunter J!, Morgan JIw, Merigan WH,eal. The susceptibility of the 意义 retina to photochemical damage from visible light. Prog Retinal Eye Res 参考文献 012;31(1):28-42 Wong WL,sux,Lix,eal. Global prevalence of age-rld18过贵元,丁波,李永生,等.应用OCT检测年龄相关性黄斑变性的 degeneration and disease burden projection for 2020 and 2040 分析中国体视学与图像分析2015:20(3):296-300 tie review and meta- analysis. Lancet glob health2014;2(2):19李泽斌,陈子林光学相干断层扫描在病理性近视黄斑病变中的 应用医学综述2012;18(10):1575-1577 2张红霞贾伟平,包玉倩,等.免散瞳眼底拍照对糖尿病视网膜病变20 Chen cy, Wong Y, Heroin wJ,etat. Intravitreal bevacizumab 筛查效果的评价.中国糖尿病杂志2007;15(7):395-396 Avastin)for neovascular age-related macular degeneration a short term 3 The Age-Related Eye Disease Study Research Group. The Ag study. Am J Opthalmol 2007: 143(3): 510-512 Related eve disease study( AREDS): design implications. AREDS21苏鹏,晏世刚,孔祥斌,等光学相干断层扫描在老年性黄斑变性 report no. 1. Control Clin Trials 1999; 20(6): 573-600 诊断中的应用价值研究中国医药科学2016;6(4):192-202 4 Bearelly s, Cousins sw. Fundus autofluorescence imaging in age-22周优优渗出性老年性黄斑变性的光学相干断层扫描观察.中国 related macular degeneration and geographic atrophy. Ade Exp Med Biol卫生产业2013:10(36):17-119 23 Brown DM. Michels M. Kaiser PK. et al. Ranibizumab versus 5 Mokwa NF, Ristau T, Keane PA. et al. Grading of age-related verteporfin photodynamic therapy for neovascular age -related macular macular degeneration: comparison between color fundus degeneration: two-year results of the ANCHOR study. Ophthalmolo fluorescein angiography, and spectral domain optical coherence 2009: 116(1): 57-65 tomography. J Ophthalmol 2013; 2013(5): 385915 24 Rosenfeld PJ. Brown DM, Heier JS, et al. Ranibizumab for neovascular 6 Peee A, Sannace C, Menchini U, et al. Fluorescein angiography and age-related macular degeneration. N Engl J Med 2006: 355(14 green angiography for identifying occult choroidal neovascularization in age -related macular degeneration. Eur J 25 Fung AE, Lalwani GA, Rosenfeld PJ, ef al. An optical coherence Ophthalmol2005;15(6):759-763 tomography-guided, variable dosingregimen with intravitreal ranibizumab Landa G, Springer A, Bukelman A, ef al. The diagnostic contribution Lucentis for neovascular age -related macular degeneration. Am J of indocyanine green to fluorescein angiography in fellow drusen eyes of Ophthalmol patients with wet age-related macular degeneration. Eur J Ophthalmol 26 Lalwani GA, Rosenfeld PJ, Fung AE, et al. A variable-dosing regimen 2007;17(4):615-619 with intravitreal ranibizumab for neovasc 8陈松,韩梅,王兰惠,等渗出型老年黄斑变性的吲哚菁绿血管造影 degeneration year2 of the pronto study. Im J Ophthalmol2009;148 图像特征.眼科研究2003:21(4):428-430 (1):43-58 9魏丽丽眼底荧光血管造影在年龄相关性黄斑变性患者中的临床27 Pauleikhoff d, Kirchhof e. Retreatment eriteria in anti- VEGF therapy 应用价值江苏医药2014;40(12):1470-1471 of exudative AMD: eritieal analysis of present regimes and new 10付校楠,彭慧眼底自发荧光技术在部分视网膜疾病中的应用进 morphological definition of" lesion activity". Graefe Arch Clin Exp 展眼科新进展2013;33(4):393-396 Ophthalmo2011;249(5):631-632 11 Delori FC, Douglas G, Gogerand CK. Age-related accumulation and 28 Jia Y, Tan O, Tokayer J, et al. Split-spectrum amplitude spatial distribution of lipofuscin in RPE of normal subjects. Intest decorrelation angiography with optical coherence tomography. Optics Ophthalmol Vis Sci2001;42(8):1855-1866 Express2012;20(4):4710-4725 12 Robson AG, Moreland JD, Pauleikhoff D, ef al. Macular pigment 29 Spaide RF, Klancnik JM, Cooney MJ. Retinal vascular layers imaged density and distribution: comparison of fundus autofluorescent with by fluorescein angiography and optical coherence tomography minimum motion photometry. Vis Res 2003: 43(16): 1765-1775 angiography. JAMA Ophthalmol 2014; 133(1): 45-50 13 Holz FG. Bindewaldwittich A Fleckenstein M. et al. Progression of 30 Jia Y, Bailey ST, Wilson DJ, et aL. Quantitative optical coherence geographic atrophy and impact of fundus autoflorescence patterns in age- tomography angiography of choroidal neovascularization in age -related related macular degeneration. Am J Opthalmol 2007: 143(3): 463-472 macular degeneration. Ophthalmology 2014: 121(7): 1435-1444 1858量来证实其在 CNV 临床检测应用中更好的灵敏度及特 异性。 5 小结 综上所述,眼科影像学检查在近年来取得了很大进 展,目前已广泛应用于 AMD 的临床诊断,并且为疾病的 发病机制、疗效评价及预后判断提供可靠依据。 未来应 该将影像技术与数码技术进一步结合,在对 AMD 定性 分析的 基 础 上 进 行 定 量 分 析, 可 能 更 具 临 床 和 研 究 意义。 参考文献 1 Wong WL, Su X, Li X, et al. Global prevalence of age - related macular degeneration and disease burden projection for 2020 and 2040: a systematic review and meta-analysis. Lancet Glob Health 2014;2 (2): e106-116 2 张红霞,贾伟平,包玉倩,等. 免散瞳眼底拍照对糖尿病视网膜病变 筛查效果的评价. 中国糖尿病杂志 2007;15(7):395-396 3 The Age - Related Eye Disease Study Research Group. The Age - Related Eye Disease Study ( AREDS): design implications. AREDS report no. 1. Control Clin Trials 1999;20(6):573-600 4 Bearelly S, Cousins SW. Fundus autofluorescence imaging in age - related macular degeneration and geographic atrophy. Adv Exp Med Biol 2010;664:395-402 5 Mokwa NF, Ristau T, Keane PA, et al. Grading of age - related macular degeneration: comparison between color fundus photography, fluorescein angiography, and spectral domain optical coherence tomography. J Ophthalmol 2013;2013(5):385915 6 Pece A, Sannace C, Menchini U, et al. Fluorescein angiography and indocyanine green angiography for identifying occult choroidal neovascularization in age - related macular degeneration. Eur J Ophthalmol 2005;15(6):759-763 7 Landa G, Springer A, Bukelman A, et al. The diagnostic contribution of indocyanine green to fluorescein angiography in fellow drusen eyes of patients with wet age - related macular degeneration. Eur J Ophthalmol 2007;17(4):615-619 8 陈松,韩梅,王兰惠,等. 渗出型老年黄斑变性的吲哚菁绿血管造影 图像特征. 眼科研究 2003;21(4):428-430 9 魏丽丽. 眼底荧光血管造影在年龄相关性黄斑变性患者中的临床 应用价值. 江苏医药 2014;40(12):1470-1471 10 付校楠,彭慧. 眼底自发荧光技术在部分视网膜疾病中的应用进 展. 眼科新进展 2013;33(4):393-396 11 Delori FC,Douglas G,Gogerand CK. Age - related accumulation and spatial distribution of lipofuscin in RPE of normal subjects. Invest Ophthalmol Vis Sci 2001;42(8):1855-1866 12 Robson AG, Moreland JD, Pauleikhoff D, et al. Macular pigment density and distribution; comparison of fundus autofluorescene with minimum motion photometry. Vis Res 2003;43(16):1765-1775 13 Holz FG,Bindewaldwittich A,Fleckenstein M, et al. Progression of geographic atrophy and impact of fundus autoflorescence patterns in age￾related macular degeneration. Am J Opthalmol 2007;143(3):463-472 14 Karadimas P,Bouzas EA. Fundus autofluorescence inaging in serous and drusenoid pigment epithelial detachments associated with age-related macular degeneration. Am J Opthalmol 2005;140(6):1163-1165 15 宣懿,赵培泉,彭清. 年龄相关性黄斑变性患者眼底玻璃膜疣的自 发荧光特征. 中华眼科杂志 2010;46(9):708-713 16 Bindewald A, Bird AC,Dandekar SS,et al. Classification of fundus autofluorescence patterns in early age - related macular disease. Invest Ophthalmol Vis Sci 2005;46(9):3309-3314 17 Hunter JJ, Morgan JIW, Merigan WH, et al. The susceptibility of the retina to photochemical damage from visible light. Prog Retinal Eye Res 2012; 31(1):28-42 18 过贵元,丁波,李永生,等. 应用 OCT 检测年龄相关性黄斑变性的 分析. 中国体视学与图像分析 2015;20(3):296-300 19 李泽斌,陈子林. 光学相干断层扫描在病理性近视黄斑病变中的 应用. 医学综述 2012;18(10):1575-1577 20 Chen CY, Wong JY, Heroit WJ, et al. Intravitreal bevacizumab (Avastin) for neovascular age-related macular degeneration:a short term study. Am J Opthalmol 2007;143(3):510-512 21 苏鹏,晏世刚,孔祥斌,等. 光学相干断层扫描在老年性黄斑变性 诊断中的应用价值研究. 中国医药科学 2016;6(4):192-202 22 周优优. 渗出性老年性黄斑变性的光学相干断层扫描观察. 中国 卫生产业 2013;10(36):117-119 23 Brown DM, Michels M, Kaiser PK, et al. Ranibizumab versus verteporfin photodynamic therapy for neovascular age - related macular degeneration: two - year results of the ANCHOR study. Ophthalmology 2009; 116(1):57-65 24 Rosenfeld PJ,Brown DM,Heier JS,et al. Ranibizumab for neovascular age - related macular degeneration. N Engl J Med 2006; 355 ( 14 ): 1419-1431 25 Fung AE, Lalwani GA, Rosenfeld PJ, et al. An optical coherence tomography-guided, variable dosingregimen with intravitreal ranibizumab (Lucentis) for neovascular age - related macular degeneration. Am J Ophthalmol 2007;143(4):566-583 26 Lalwani GA,Rosenfeld PJ,Fung AE,et al. A variable-dosing regimen with intravitreal ranibizumab for neovascular age - related macular degeneration year 2 of the PrONTO Study. Am J Ophthalmol 2009;148 (1):43-58 27 Pauleikhoff D,Kirchhof B. Retreatment criteria in anti-VEGF therapy of exudative AMD: critical analysis of present regimes and new morphological definition of “ lesion activity 冶. Graefes Arch Clin Exp Ophthalmol 2011;249(5):631-632 28 Jia Y, Tan O, Tokayer J, et al. Split - spectrum amplitude - decorrelation angiography with optical coherence tomography. Optics Express 2012;20(4):4710-4725 29 Spaide RF,Klancnik JM,Cooney MJ. Retinal vascular layers imaged by fluorescein angiography and optical coherence tomography angiography. JAMA Ophthalmol 2014; 133(1):45-50 30 Jia Y,Bailey ST, Wilson DJ, et al. Quantitative optical coherence tomography angiography of choroidal neovascularization in age - related macular degeneration. Ophthalmology 2014;121(7):1435-1444 1858 国际眼科杂志 2017 年 10 月 第 17 卷 第 10 期 http: / / ies. ijo. cn 电话:029鄄82245172 85263940 电子信箱:IJO. 2000@ 163. com