河北医科大学药学院 Structural Diversity-抗疟霉素 Ingenamine G 7 plasmomy cin A G was iveladm Symmetric Marine Compounds Svmmetric Marine Compounds CyclostellettaminesG.H.I.K and L Aerothionin nSwGK Lissoclibadin omet oa Indo 13n工4 天然药化教研室史清文教授 10 河北医科大学药学院 天然药化教研室史清文教授 10 Structural Diversity-抗疟霉素 The structure elucidation of Aplasmomycin A was performed by X-ray crystallographic methods. To the surprise, the molecule contained an unexpected Boron atom in the center of the complex. Nakamura, H.; et al. Antibiot. 1977, 30, 714. Aplasmomycin A Borophycin Ingenamine G Ingenamine G was isolated from marine Sponge Pachychalina sp. Which displayed cytotoxic activity against HCT-8 (colon), B16 (leukemia), and MCF-7 (breast) cancer cell lines. Oliveira, J. H. H. L. et al. J. Nat. Prod. 2004, 67, 1685. Cyclostellettamines G, H, I, K and L Cyclostellettamines G, H, I, K and L were also isolated from marine sponge Pachychalina sp. TL 1992, 33:2059 Symmetric Marine Compounds Aerothionin The sponges Aplysia aerophoba and Verongia thiona have yielded the antibiotic substance, Aerothionin having a spiro cyclohexadienylisoxazole skeleton. Encarnacion, R. D.; Sandoval, E.; Christophersen, C. J. Nat. Prod. 2000, 63, 874. Symmetric Marine Compounds The red Antarctic alga Delisea pulchra has been found to elaborate three new dimeric halogenated furanones, pulchralides A–C. S. Ankisetty, et al. J. Nat. Prod., 2004, 67, 1295. Bacteria of the genus Nocardiopsis, found in deep-sea Pacific sediments (3000 m) contained a new cyclic tetrapeptide. J. Shin, et al. J. Nat. Prod., 2003, 66, 883. Lissoclibadin was isolated as a mildly antibacterial component of an Indonesian Lissoclinum cf. badium. Lissoclibadin H. Liu, S. B. Pratasik, T. Nishikawa, T. Shida, K. Tachibana, T. Fujiwara, H. Nagai, H. Kobayashi and M. Namikoshi, Tetrahedron Lett., 2004, 45, 7015