河北医科大学药学院 深海海洋生物 2.Feature of Secondary Metabolites from Marine Organisms miedCoaiea Halomon Contain Halide 实 Structural Diversity Structural Diversity 天然药化教研室史清文教授 9河北医科大学药学院 天然药化教研室史清文教授 9 南极章鱼在南极罗斯海水域水下1000米深处 这种珠光宝气的乌贼学名为 “Histioteuthis bonelli”，生 活于大西洋中脊附近500米到 2000米深的海水中。 深海海洋生物 2. Feature of Secondary Metabolites from Marine Organisms  Limited Content  Structural Diversity  Stronger/Diversity Activity  Often Contain Halide and Sulfate  Unusual Metabolite Containing N O O O OH O Sesterterpenoid from Japanese Sponge Br Cl Br Br Cl Cl Halogenated Monoterpene Cl Cl Me Br Br Me Red algal Halomon is a polyhalogenated monoterpene first isolated from the marine red algae Portieria hornemannii. Halomon has attracted research interest because of its promising profile of selective cytotoxicity that suggests its potential use as an antitumor agent. Halomon Portieria hornemannii 松香藻 O AcO AcO AcO AcO I Cl O O O H O O AcO AcO AcO Cl O O O H I O Dichotellides A-E, five new iodine-containing briarane type diterpenoids from the South China Sea gorgonian Dichotella gemmacea.(柳珊瑚) Liu Yonghong Tetrahedron 2011, 67 : 1245-1250 Contain Halide S S S S S NH2 OMe MeO Varicin was isolated from algae Lissoclinun vareau, 中分离的第一个天 然存在的环状多硫化合物，Varicin有十分显著的抗肿瘤活性。在人肠癌 试管混合实验时，其活性比已知的治疗药物5-氟尿嘧啶细胞毒性高100倍。 Varicin Gymnorrhizol, an unusual macrocyclic polydisulfide possessing an unprecedented carbon skeleton, has been isolated from a mangrove Bruguiera gymnorrhiza (Guangxi). 郭跃伟, TL 2004, 45, 5533. Structural Diversity O OH Cl N Cl Cl Cl OH NaO3SO OH OH OSO2NHMe Faulkner D. J. J. Am. Chem. Soc. 1977, 99, 7367. Faulkner D. J. Tetrahedron. 1999, 55, 8323. Structural Diversity Marine Sponges Special residue 二氯代亚胺基 扩大了天然存在 的基团的概念