盖布瑞尔法可得比较纯产品： R +X-CHCOOR'→0 CHCOOR' COOH R NaOH/H,O H2N-CHCOOH+R'OH Or NH2NH2 COOH 3、由丙二酸酯合成： 例： COOEt COOEt ①H2/Pt CH2 +HNO2 C=NOH ②醋酐 COOEt COOEt COOEt Organic Chem Organic Chem 盖布瑞尔法可得比较纯产品： 3、由丙二酸酯合成： 例： NK O O + R X CHCOOR' N O O CHCOOR' R NaOH/H2O COOH COOH + R H2N CHCOOH + R'OH Or NH2NH2 COOEt CH2 COOEt + HNO2 COOEt C COOEt NOH ①H2 / Pt ②醋酐 COOEt HC COOEt NH CCH3 O