RESPONSE TO IMPLANTS: WOUND HEALING Surgical Implantation Inc. time Vascular Response Acute Clotting Inflammation Phagocytosis Granulation Neovascularization New Collagen Synthesis Tissue

biologically active model of ECM acts as an insoluble regulator of cell function image removed due to copyright considerations

RESPONSE TO IMPLANTS WOUND HEALING flury Vascular Response Inflammation Tissue of labile Tissue of and stable cells Permanent cells Framework framework Scar Intact Destroyed

UNIT CELL PROCESSES Regulator UCP Cell Matrix Product Regulator Connect. ECM Mitosis Tiss. Adhesion Sy Synthesis Epithelia |Protein Migration Muscle Collagen

Outline of three lectures on Irreversible Healing of Extracellular Matrix. A. Irreversible healing of ECMs in different organs. B. Structure and function of naturally occurring ECMs. C. Synthesis of biologically active ECM models

BIOMATERIALS-TISSUE INTERACTIONS: \Tools\ for Understanding the Molecular, Cellular, and Physiological, Bases of the Tissue Response to Implants M. Spector, Ph. D. and I. V. Yannas, Ph.D. BIOMATERIALS-TISSUE INTERACTIONS

Introduction. Chapter 1. Irreversible Healing of Extracellular Matrix. Chapter 2. Cell-Matrix Interactions. Chapter 3. Synthesis of Tissues and Organs. TEXT: I. V. Yannas. Tissue and Organ Regeneration in Adults. New York: Springer, 2001

The Cell and Its Membrane Molecules Plasma membrane-5nm Rough ER Smooth ER Nucleus-3-10 um Nucleolus Nuclear pore -Golgi complex Extracellular

Teaching points I. Background information II. Introduction to the passage III. Text analysis IV rhetorical devices V. Questions for discussion

TWO-Terminal Ic DEVICES Temperature Transducer AD590 FEATURES PIN DESIGNATIONS Linear Current Output: 1 HA/K Wide Range:-55C to+150C Probe Compatible Ceramic Sensor Package