Much of the catalytic power of enzymes comes from their bringing sub- strates together in favorable orientations in enzyme-substrate (ES)com- plexes. The substrates are bound to a specific region of the enzyme called the active site. Most enzymes are highly selective in their binding

Announcement \Chapter 8 Enzymes: Basic Concepts and Kinetics\ in Lubert Stryer's \Biochemistry\ (Fourth Edition) will be used as my major lecture material, which is available for you to Xerox from your TAs. Chapter 8 in Lehninger's“ Principles of Biochemistry can be used as a reference

ENZYMES ARE HIGHLY SPECIFIC Enzymes are highly specific both in the reaction catalyzed and in their choice of reactants, which are called substrales. An enzyme usually cata- lyzes a single chemical reaction or a set of closely related reactions. Side

Questions for Archaea 1. List the differences between Bacterial and Archaeal Cell Membrane and Cell Walls. 2. What archaea have you learned so far? 3. Where to isolate halophilic Archaea? 4. What are the physiological features of halophiles?

Archaeal Membranes and Cell Wall Archaea lack fatty acids, instead have hydrocarbon moieties bonded to glycerol by ether (instead of ester) linkages Glycerol diethers and diglycerol tetraethers are the major classes of lipids present in Archaea Archaea do not contain muramic acid and D-amino acids in Bacteria

1. List the differences between Bacterial and Archaeal Cell Membrane and Cell Walls. The differences between bacterial& archaeal cell membrane and cell walls: bacteria |archaea Cell membrane

一、解释下列名词(共40分,每题4分) 1、激光共焦点扫描显微镜(laser scanning confocal microscopy) 2、功能基因组学(functional genomics) 3、胶原(collagen) 4、G蛋白偶联受体( protein-linked- receptor)

武汉大学生命科学学院：《分子生物学》英文版 Intro 课程介绍

Gene,5/e--- Watson et al.(2004) Part: Chemistry and Genetics Part ll: Maintenance of the Genome Part Ill: Expression of the Genome Part IV: Regulation Part V: Methods

一、名词解释(每题2分) 1、近等基因系 2、结构域互换 3、e-dna 4、基因转换(gene comversion) 5、微排列(microarrang) 6、双向电泳