C. Cell-Matrix Interactions A. How cells pull onto and deform the matrix to which they attach themselves. B. Cell-matrix interactions control the spontaneous closure of wounds in organs. C. What happens when regeneration is induced?

BIOMATERIALS-TISSUE INTERACTIONS BIOMATERIAL TISSUE Strength ize scale IOnm 100nm lum 10 um 100 um Imm Modulus of Elasticity Fracture mechanics

Outline 1. Irreversible injury 2. Regenerative and nonregenerative tissues 3. Antagonistic relation between contraction and regeneration 4. Present theory: Selective inhibition of contraction necessary but not sufficient for regeneration 5. Mechanism

ELEMENTS FOR TISSUE REGENERATIONENGINEERING CELLS Autologous, Adult (pulp and bone marrow stromal stem cell)

Methodology of Organ Synthesis A Skin B Conjunctiva C. Peripheral nerves D. simplest synthetic pathways

A. Symbolism of organ synthesis. B. The central question of organ synthesis. C. What is required to synthesize an organ? D. Trans-organ rules of synthesis

In vitro maturation of Xenopus oocytes and assay of maturation-promoting factor(MPF) Progesterone Sperm

Chapter 2 Primary Sedimentary Structures Main types of bedding Determination of younger direction of beds from primary structures Types of stratigraphic break Angular unconformity Soft sedimentary structures

Configuration, mastication, fixedness

Repair(修复) As cells and tissues are being injured, events that contain the damage and prepare the surviving cells to replicate are set into motion