Medical Genetics Multifactorial inheritance is responsible for the greatest number of individuals that will need special care or hospitalization because of genetic diseases
7.1 Introduction 7.2 Codon-anticodon recognition involves wobbling 7.3 tRNA contains modified bases that influence its pairing properties 7.4 (There are sporadic alterations of the universal code) 7.5 tRNAs are charged with amino acids by synthetases 7.6 Accuracy depends on proofreading 7.7 Suppressor tRNAs have mutated anticodons that read new codons 7.8 The accuracy of translation 7.9 tRNA may influence the reading frame
2.1 Introduction We can think about mapping genes and genomes at several levels of resolution: A genetic (or linkage) map identifies the distance between mutations in terms of recombination frequencies. A linkage map can also be constructed by measuring recombination between sites in genomic DNA
Genes vary in natural populations. Gene Variation Is the Raw Material of Evolution. Selection acts on the genetic variation present in populations, favoring variants that increase the likelihood of survival and reproduction
1. A brief history of understanding protein metabolism; 2. The studies leading to the deciphering of the genetic codes; 3. The pathway leading to the synthesis of a functional protein; 4. Current understanding on protein targeting and degradation
Professor and Chairman Department of Pediatrics, Tongji Hospital Director, Center for the Diagnosis of Genetic Metabolic Diseases Tongji Medical College Huazhong University of Science and Technology Adjunct Professor
