Major Steps in Discovery Stage Target generation and selection Development Method set-up Method validation Technique assesment Assay development and validation Automation Optimization Compound Library High throughput screens Combinatorial chemistry Library chemistry Natural products Lead confirmation and chemistry Preliminary PK investigation SAR In vivo functional tests

Chapter 1 Chemistry is a Science of Change water molecule is consisted of one oxygen(氧) atom and two hydrogen(氢) atoms A cup of water contains about 1024 water molecules

1 Introduction to medicinal chemistry 2 General priciples of drug action 3 Physico chemical properties of organic medicinal agents 4 Chemistry of prodrugs 5 Drug metabolism 6 General anesthetics 7 Sedative-hypnotic drugs 8 Psychoactive drugs 9 Antiepileptic agents 10 Cholinergic and anticholinergic drugs 11 Adrenergic drugs 12 Adrenoreceptor blocking drugs 13 Skeletal muscle relaxants 14 Antihistamines 15 Narcotic analgesics 16 Narcotic antagonists 17 Antitussives 18 Non-steroidal antiinflammatory drugs 19 Local anesthetics 20 Diuretics 21 Hypoglycemic agents 22 Thyroid and antithyroid drugs

9.1 The ionic radii ratio and the coordination polyhedra of ions 9.2 The crystal structures of Some typical ionic compounds 9.3 Lattice energy 9.4 Ionic radii 9.5 The Pauling rule of ionic crystal structure 9.6 Structural chemistry of silicates 9.7 Crystals of Functional Materials

《大学化学 Chemistry》课程PPT教学课件（英文）Chapter 1：Chemistry is a Science of Change Chapter 2 Elements of Chemistry

Carbon atoms have the ability to link together and form molecules made up of many carbon atoms. The branch of chemistry that is the study of carbon-containing compounds is known as organic chemistry(有机化学) 13 million known organic compounds and 100,000 new ones are added annually Only 200,000-300,000 known inorganic compounds

我的宗旨: To our students, whose enthusiasm and curiosity have often inspired us, and whose questions and suggestions have sometimes taught us Chemistry the central science Chemistry has often been called the central science, because a basic knowledge of chemistry is

ORGANIC CHEMISTRY The first question we need to ask ourselves s What is“ Organic Chemistry\?

1. Reaction Rate & Rate Equation 2. Theoretical Consideration – SCT & TST 3. Microscopic Mechanism

第二章立体化学(Steric Chemistry) 立体化学 分子结构 一、对映异构 (一)分子的对称性 对称要素 对称分子 非对称分子 不对称分子 (二)含一个手性中心的分子 手性中心为碳原子的分子