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REVIEWS The Art and Science of Total Synthesis at the Dawn of the Twenty-First Century** K. C. Nicolaou, Dionisios Vourloumis, Nicolas Winssinger, and Phil S. Baran Dedicated to Professor E. J. Corey for his outstanding contributions to organic synthesis At the dawn of the twenty-first cen-of the most exciting and important covery and invention of new synthetic tury, the state of the art and science of discoveries of the twentieth century in strategies and technologies; and explo- vnth
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4.1 Introduction 4.2 Classification of Cam Mechanisms 4.3 Cam Nomenclature 4.4 Motion events 4.5 Graphical Synthesis of Cam Contour 4.6 Analysis Synthesis of Cam Contour 4.7 Considerations of Cam Mechanisms Synthesis
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B. Conjunctiva synthesis in vivo (regeneration) 1. Structure and function of conjunctiva. 2. Clinical effects of conjunctival scarring. 3. Anatomically well-defined defect. 4. Synthesis of conjunctival stroma, followed by re-epithelialization
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C. Synthesis of biologically active scaffolds (regeneration templates) 1. History of biologically active scaffolds (regeneration templates). 2. Physical chemistry of collagen: Melting of collagen quaternary structure (thromboresistance). Melting of collagen tertiary structure (gelatinization). 3. Synthesis of ECM analogs: lonic complexation
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4.1 Introduction 4.2 Classification of Cam Mechanisms 4.3 Cam Nomenclature 4.4 Motion events 4.5 Graphical Synthesis of Cam Contour 4.6 Analysis Synthesis of Cam Contour 4.7 Considerations of Cam Mechanisms Synthesis
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1. Reduction(fixation)of N, into ammonia(NH3 or NH*) 2. Synthesis of the 20 amino acids 3. Synthesis of other biomolecules from amino acids 4. The de novo pathways for purine and pyrimidinebiosynthesis 5. The salvage pathways for purine and pyrimidine reuse
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2.1 Introduction 2.2 Micro-organisms as catalysts of organic synthesis 2.3 Enzyme preparations versus whole cell processes 2.4 Scale of production 2.5 Modes of operation of bioprocesses 2.6 Biotechnological processes verses chemical synthetic processes
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Lecture 11: Molecular Design and Synthesis of Biomaterials Il: Inorganic Biomaterials Last time: hydrogel applications: molecular imprinting and responsive drug delivery Today biomineralization and biomimetic inorganic/organic composites Inorganic biomaterials Reading L A. Estroff and A D. Hamilton, ' At the interface of organic and inorganic chemistry
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Molecular Principles of Biomaterials Spring 2003 Lecture 2: Molecular Design and Synthesis of Biomaterials I: Biodegradable Materials Chemistry of Biodegradable Materials Hydrolytically degraded biomaterials Common hydrolytically unstable linkages Ester
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Motion sickness: a synthesis and evaluation of the sensory conflict theor Man Vehicle Laboratory, Massachuserrs Institute of Technology, Cambridge, MA 02139, U.S.A Received December 15. 1988 M. 1990. Motion sickness: a synthesis and evaluation of the sensory conflict theory. Can. J. Physiol. Pharmacol erebral ischemia
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