ELEMENTS FOR TISSUE REGENERATIONENGINEERING CELLS Autologous, Adult (pulp and bone marrow stromal stem cell)

Outline 1. Irreversible injury 2. Regenerative and nonregenerative tissues 3. Antagonistic relation between contraction and regeneration 4. Present theory: Selective inhibition of contraction necessary but not sufficient for regeneration 5. Mechanism

Chapter 2. Cell-Matrix Interactions. [that determine biomaterials function in vitro and in vivo] A. How cells pull onto and deform the matrix to which they attach themselves. B. Cell-matrix interactions control the spontaneous closure of wounds in organs. C. What happens when regeneration is induced?

SACHUSE Massachusetts Institute of Technology Harvard Medical School Brigham and Women's/Massachusetts General Hosp

BIOMATERIALS-TISSUE INTERACTIONS: \Tools\ for Understanding the Molecular, Cellular, and Physiological, Bases of the Tissue Response to Implants M. Spector, Ph. D. and I. V. Yannas, Ph.D. BIOMATERIALS-TISSUE INTERACTIONS

Introduction. Chapter 1. Irreversible Healing of Extracellular Matrix. Chapter 2. Cell-Matrix Interactions. Chapter 3. Synthesis of Tissues and Organs. TEXT: I. V. Yannas. Tissue and Organ Regeneration in Adults. New York: Springer, 2001

TISSUE Tissue is a biological structure made up of cells of the same type. - Cells of the same phenotype(e., same genes expressed). An aggregation of morphologically similar cells and associated extracellular matrix acting together to perform one or more specific functions in the body. - There are four basic types of tissue: muscle, nerve, epithelia, and connective. An organ is a structure made up of or more tissues

The wheel of retailing Gain entry with low prices Gain trust and loyalty Add offerings and raise prices Differentiate from new no-frills entrants

The Wheel of retailing GG ain entry with low prices rain trust and loyalty Add offerings and raise prices Differentiate from new no -frills entrants

How to make a better device Good performance faster and less power consumed Low cost more compact and use less area