American Legion Convention in 1976 in Philadelphia hotel – Respiratory distress and fever – 200 affected – 34 died

General Aspects Ecology – Found throughout the environment Very simple nutritional requirements – Not usually in normal flora unless hospitalized or immunocompromised

Diversity of species Ecology – Found worldwide in soil, water, vegetation, and microbial flora of animals and humans – Some are always associated with disease

Comparison of Meningococcus and Gonococcus Pathobiology Similarities: – Both diploccocci – Share about 80% DNA – Neither makes exotoxin; both make endotoxin – Both are relatively good colonizers

Staphylococci Important human pathogen – Causes both relatively minor and serious diseases One of the hardiest of the non￾sporeforming bacteria – Can exist on dry surfaces for a long period – Relatively heat-resistant; temperature range

第一节 基本概念与原理 Basic Conceptions and Principle 第二节 原核基因转录调节 Regulation of Prokaryotic Gene Transcription 第三节 真核基因转录调节 Regulation of Eukaryotic Gene Transcription

Production of Ab and Activation of Macrophages and Cytotoxic T Cells T-Dependent T-Independent

Definition – Soluble substances that alter normal metabolism of host cells with deleterious effects on the host Host range – Known for bacteria, but possible that they play a role in diseases caused by fungi

第一节 物质代谢的特点 1、整体性 各种物质代谢之间互有联系,相互依存

《生物分离工程》课程教学资源（PPT课件）色谱学基础