Similar to Viruses Atypical Agents Small Filterable Need host cells No machinery for energy generation of protein synthesis

Ab initio =from the beginning in strictest sense uses first principles, not information about other protein structures In practice, all methods rely on empirical observations

Algorithms for detecting structure similarity Dynamic Programming works on 1D strings- reduce problem to this cant accommodate topological changes example: Secondary Structure Alignment Program(SSAP) 3D Comparison/Clustering

Review -Homology Modeling Identify a protein with similar sequence for which a structure has been solved (the template) Align the target sequence with the template Use the alignment to build an approximate structure for the target

Outline Brief review of protein structure chou -Fasman- predictions Garnier, Osguthorpe and Robson Helical wheels and hydrophobic moments Neural networks Nearest neighbor methods Consensus prediction approaches

As the first food of infant mammals, milk provides an important source of fat, protein, carbohydrate, vitamins and minerals, essential to the development of tissue and bone, and the growth of young. Milk is also a substance used beneficially by humans of all ages, both as a food in its own right and as a material for the production of milk products and milk-based food ingredients

一、英译中( Translate) 1. primary messenger 2. calcium homeostasis 3. cell surface receptor 4. protein kinase, PK

蛋白质 (protein)是一类重要的生物大分子, 是告命的物质基础。分子中主要的元素组 成是:C、H、O、N、S等。其中N元素 的含量相对稳定,约为16%,故每克氮相 当于6.25克蛋白质

105 assembly and disassembly of cytoskeleton Assembly: In two distinct phases: slower nucleation andrapidelongation The factors influncing assemble. associated protein, MAPS, Ca, Mg, ATP, GIP Gmodmilling odel

第一节概念 节肢动物是无脊椎动物的重要门类,其种类繁多,全世界已记录的节 肢动物约占动物种类总数的87%。节肢动物分布广泛,几乎有生物存在的 生境都有节肢动物的存在,甚至有些种类是寄生人体及其它动物的寄生 虫。节肢动物重要特征包括:虫体两侧对称,身体及对称分布的附肢均分 节,因此称节肢动物;具有由几丁质及醌单宁蛋白( quinone tanned protein)组成的坚硬的外骨骼( exoskeleton);循环系统开放式,整个循环 系统的主体称为血腔,内含血淋巴;发育史大多经历蜕皮( ecdysis,molt) 和变态( metamorphosis)