Radioisotope tracer experiments showed that the porphyrin(卟啉) ring of the heme groups in mammals are made from 8 Gly and 8 succinyl-COA (Glu in plants and bacteria). Deficiency of enzymes leading to heme biosynthesis cause diseases called porphyrias (The degradation of heme yields bilirubin, a linear tetrapyrrole derivative, and the typical pigments found
1. Reduction(fixation)of N, into ammonia(NH3 or NH*) 2. Synthesis of the 20 amino acids 3. Synthesis of other biomolecules from amino acids 4. The de novo pathways for purine and pyrimidinebiosynthesis 5. The salvage pathways for purine and pyrimidine reuse
An overview on D-glucose metabolism The major fuel of most organisms,4'o=-2840kJ/mole if completely oxidized to CO, and H, via the glycolysis pathway, citric acid cycle and oxidative phosphorylation (generating ATP). Can also be oxidized to make NADPH and ribose-5-P via the pentose phosphate pathway
6.1 An Introduction to Enzymes 191 H20 in the presence of oxygen is a highly exergonic 6.2 How Enzymes Work 193 process, releasing free energy that we can use to think an I 6.3 Enzyme Kinetics as an Approach to Understanding main on the shelf for years without any obvious con-