The primary purpose of a buffer is to control the pH of the solution. Buffers can also play secondary roles in a system, such as controlling ionic strength or solvating species, perhaps even affecting protein or nucleic acid structure or activity. Buffers are used to stabilize nucleic acids, nucleic acid–protein complexes, proteins
25.1 Introduction 25.2 Oligosaccharides are added to proteins in the ER and Golgi 25.3 The Golgi stacks are polarized 25.4 Coated vesicles transport both exported and imported proteins 25.5 Different types of coated vesicles exist in each pathway 25.6 Cisternal progression occurs more slowly than vesicle movement 25.7 Vesicles can bud and fuse with membranes 25.8 SNAREs control targeting 25.9 The synapse is a model system for exocytosis 25.10 Protein localization depends on specific signals 25.11 ER proteins are retrieved from the Golgi 25.12 Brefeldin A reveals retrograde transport 25.13 Receptors recycle via endocytosis 25.14 Internalization signals are short and contain tyrosine
PROGRESS IN NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY ELSEVIER Progress in Nuclear Magnetic Resonance Spectroscopy 38(2001)83-114 www.elsevier.nl/locate/pnmrs NMR studies of protein -DNA interactions N. Jamin“,F.Ton
香港中文大学:《CMSC5719 Seminar》课程教学资源(讲义)Lecture 10 An Introduction to Bioinformatics and its application in Protein-DNA/Protein Interactions Research and Drug Discovery
DISCOVERy OF THE ROLE OF UBIQUITIN IN PROTEIN DEGRADATION HISTORICAL FACTS Courtesy of Sam Griffiths-Jones. Used with permission Source: \Peptide models for protein beta-sheets hD thesis, University of Nottingham, 2001 8(1975)Ubiquitin was first isolated by Gideon Goldstein and colleagues from the thymus(reason why it was originally thought to be a thymic hormone)