《中国细胞生物学学报》：T细胞抗原受体的结构与功能研究进展（中国科学院上海生命科学研究院：施小山、李伦乙、郭兴东、许琛琦）

1.1 生物传感器概述 生物传感器是一个非常活跃的研究和工程技术领域，它与生物信息学、生物芯片、生 物控制论、仿生学、生物计算机等学科一起，处在生命科学和信息科学的交叉区域。它们 的共同特征是：探索和揭示出生命系统中信息的产生、存储、传输、加工、转换和控制等 基本规律,探讨应用于人类经济活动的基本方法。生物传感器技术的研究重点是：

武汉大学生命科学学院：《分子生物学》（英文版）Intro 课程特点与目标 Mission & Goal

Part I: Chemistry and Genetics Part II: Maintenance of the Genome Part III: Expression of the Genome Part IV: Regulation Part V: Methods

1.DNA Structure 2.DNA Topology 3.RNA Structure

Part I: Chemistry and Genetics Part II: Maintenance of the Genome Part III: Expression of the Genome Part IV: Regulation Part V: Methods

TOPIC 1 Principles of Transcriptional Regulation [watch the animation] TOPIC 2 Regulation of Transcription Initiation: Examples from Bacteria (Lac operon, alternative s factors, NtrC,MerR, Gal rep, araBAD operon) TOPIC 3 Examples of Gene Regulation after Transcription Initiation (Trp operon) TOPIC 4 The Case of Phage λ: Layers of Regulation

◼ What are the main challenges of translation and how do organisms overcome them? ◼ What is the organization of nucleotide sequence information in mRNA? ◼ What is the structure of tRNAs, and how do aminoacyl tRNA synthetases recognize and attach the correct amino acids to each tRNA? ◼ How does the ribosome orchestrate the translation process?

1. RNA polymerase and transcription cycle 2. The transcription cycle in bacteria 3. Transcription in eukaryotes •Molecular Biology Course

◼ All DNA is recombinant DNA. ◼ Genetic exchange works constantly to blend and rearrange chromosomes, most obviously during meiosis, when homologous chromosomes pair prior to the first nuclear division. ◼ During this pairing, genetic exchange between the chromosomes occurs. This exchange, classically termed crossing over, is one of the results of homologous recombination