susceptible host, a series of coordinated events must rcumvent both innate and adaptive immunity. One of the first and most important features of host innate immunity is the barrier provided by the epithelial surfaces of the skin and the lining of the gut. The difficulty of penetrat- ing these epithelial barriers ensures that most pathogens never gain productive entry into the host. In addition to pro viding a physical barrier to infection, the epithelia also pro duce chemicals that are useful in
part of the body to another. This is espe- ially true of lymphocytes, which circulate ly in the blood and lymph and, in common with at sites o Lymphocytes Attached to the Surface of a High-Endothelial Venule sLymphocyte Recirculation Cell-Adhesion Molecules Neutrophil Extravasation Lymphocyte Extravasation Chemokines-Key Mediators of Inflammation Other Mediators of Inflammation The Inflammatory Process
that peptides derived from the antigen be displayed within the cleft of an MHC peptide-Mhcthe m ormation of the Antigen Processing for Presentation by Class I MHC Molecules Self-MHC Restriction of T Cells Class tides that Role of Antigen-Presenting Cells Evidence for Two Processing and Presentation Pathways
of the humoral branch of the immune system Research on complement began in the 1890s, when Jules bordet at the institut pasteur in paris showed that sheep antiserum to the bacterium vibrio cholerae caused lysis of the bacteria and that heating the antiserum destroyed its bacteriolytic activity. Surprisingly, the ability to lyse the bacteria was restored to the heated serum by adding fresh serum that contained no antibodies directed a The Functions of Complement
production of plasma cells and memory B cells can be divided into three broad stages: generation of mature, immunocompetent B cells(maturation), activa- Initial Contact between b and T cells tion of mature B cells when they interact with antigen, and differentiation of activated B cells into plasma cells and memory B cells. In many vertebrates, ng humans B-Cell maturation and mice, the bone marrow generates B cells. This process
一、 MHC分子的基本结构与组织分布 Stucture and Cellular Distribution of MHC Molecules 二、 人MHC基因的结构与多样性 Structure and Polymorphism of Human MHC 三、 MHC分子的抗原肽结合单位 Peptide-Binding Unit of MHC Molecules 四、 蛋白质抗原的处理和递呈 Processing and Presentation of protein Antigens
recognition by most T cells from recognition by B iction. In most cases, both th maturati vation of ma the involver diversity o CD4\ and CD class I MHC Activat Engagement of TcR by Peptide: MHC Initiates interaction of th n antigenic Signal Transduction tide displayed though the sp
