There are many ways of cloning a disease gene, depending on what is known about the disease. We will show several typical examples in this part of the lecture

Restriction enzymes are used for cutting DNA at precise locations Vectors are used for the propagation of cloned DNA fragments Libraries of cloned DNA fragments allow searching for a specific DNA fragment

How DNA as genetic materials was established (also summarized in er including structure and components Basic properties of DNA, i xt slide)

7.1染色体组及其整倍性 7.2染色体数目变异的类型 7.3整倍体变异 7.4非整倍体变异

第一节基因突变率和时期 第二节基因突变的一般特征 第三节基因突变与性状表现 第四节基因突变的鉴定 第五节生化突变 第六节基因突变和诱发

8.1突变的概念 8.2基因突变与性状表现 8.2.1突变体的表型特性

一、 概念（16 分，每个 2 分） 1、 同源染色体 2、 复等位基因 3、显性上位作用 4、 基因定位 5、 转导

安徽医科大学：《医学遗传学》课程教学资源（课件讲稿，打印版）07-patterns of single-gene inheritance

安徽医科大学：《医学遗传学》课程教学资源（课件讲稿，打印版）08-Genetics of Common Disorders with Complex Inheritance

安徽医科大学：《医学遗传学》课程教学资源（课件讲稿，打印版）05-principles of clinical cytogenetics