第一节 真核生物基因组 第二节 真菌类的四分子分析与作图 第三节 真核生物重组的分子机制 第四节 基因转变及其分子机制 第五节 真核生物基因的删除与扩增及重排

Molecular Biology of the Gene, 5/E -- Watson et al. (2004) Part I: Chemistry and Genetics Part: Maintenance of the Genome Part Ill: Expression of the Genome Part IV: Regulation Part V: Methods

Part l: Maintenance of the genome Dedicated to the structure of NA and the processes that propagate, maintain and alter it from one cell generation to the next

There are genetic processes that rearrange DNA sequences and thus lead to a more dynamic genome structure

Occurs The borders between introns and exons are marked by specific nucleotide sequences within the pre-mRNAS

Molecular Principles of Biomaterials Spring 2003 Lecture 2: Molecular Design and Synthesis of Biomaterials I: Biodegradable Materials Chemistry of Biodegradable Materials Hydrolytically degraded biomaterials Common hydrolytically unstable linkages Ester

Lecture 7: Hydrogel Biomaterials: Structure and Physical Chemistry Last Day: programmed/regulated/multifactor controlled release for drug delivery and tissue engineering

Lecture 7: Hydrogel Biomaterials: Structure and Physical Chemistry Last Day: programmed/regulated/multifactor controlled release for drug delivery and tissue engineering

Lecture 5: Controlled Release Devices Last time: Using enzyme substrate and cytokine peptides to engineer biological recognition of synthetic polymers Today: principles of controlled release devices based on degradable polymers Synthesis of controlled release devices Theory of polymer-based controlled release

Example: HIV-1 DNA vaccine delivered with boosters to elevate Ab titers2: Mechanical and electrical devices that can provide digitized release typically require larger devices and surgical implantation(e.g. Pharm. Res. 1, 237(1984); also have high cost