How p53 and Rb pathway function may be disrupted in cancer cells Components of the pathway which are found altered in human cancers are shown in red on the diagram above p53 and Rb themselves may be inactivated by gene mutation (loss of both copies or also as in familial retinoblastoma and Li-Fraumeni syndrome where there are inherited mutations in one copy of Rb or p53 gene respectively. Alternatively

Epstein-Barr virus (EBV), is the herpesvirus that causes infectious mononucleosis and is associated with a number of cancers, particularly lymphomas in immunosuppressed persons including persons with AIDS EBV is a ubiquitous virus, so common that it has been difficult to determine whether it is the cause of certain diseases or whether it is simply there as an artifact

PROTACS: CHIMERIC MOLECULES TO TARGET PROTEINS FOR UBIQUITINATION AND (taken from KM Sakamoto, Mol. Genetics and Metabolism 77(2002)44-56) target targettargettarget target target target target target To circumvent the problem of transducing cells at

insolubility. Administration of cystamine, a transglutaminase inhibitor, reduces the To date, 10 neurological diseases, including aggregate formation, retarding the Huntington's and several ataxias, are caused development of neurological phenotype and by the lengthening of glutamine(@) tracts in prolonging the life span of brain cells in various proteins with no obvious functional or transgenic mouse models

12.1生物技术定义、主要内容和发展概况 12.2基因工程 12.3蛋白质工程、发酵工程和细胞工程简介 12.4分子诊断和基因治疗

配位化合物简称配合物,也称络合物,是一类复杂的化合物,它的存在和应 用都很广泛,生物体内的金属元素多以配合物的形式存在。例如植物中的叶绿素 是镁的配合物,植物的光合作用靠它来完成。又如动物血液中的血红蛋白是铁的 配合物,在血液中起着输送氧气的作用;动物体内的各种酶几乎都是以金属配合 物形式存在的

香菇又名香菌、香蕈、香信、冬菇、花菇等 一、香菇的营养价值 1.丰富的蛋白质、碳水化合物 2.含有18种氨基酸,其中7种人体所必需 3.维生素D原(即麦角甾体)含量高

第一节消化与吸收 第二节蛋白质 第三节碳水化合物 第四节脂类 第五节能量 第六节维生素 第七节无机盐 第八节水

病毒:是一类没有细胞结构,但有遗传复 制等生命特征,主要由核酸和蛋白质组成 的大分子生物。 病毒的宿主范围是病毒能够感染并在其中复 制的宿主种类和组织细胞种类。病毒几乎可以 感染所有的细胞生物。另一方面,病毒又具有 宿主特异性,即就某一种病毒而言,它仅能感 染一定种类的微生物、植物或动物

1 题 （略） 2 题解: 简单的同源重组，发生在同源染色体的非姊妹染色单体之间。 3题解: RecA是细菌同源重组过程中所必须的蛋白质。 RecA在细菌同源重组中的作用：