cell receptor when complexed with MHC,are called antigens. The molecular properties of antigens and he way in which these properties ultimately contribute to immune activation are central to our understanding of the mmune system. This chapter describes some of the molecu- Complementarity of Interacting Surfaces of Antibody(left) lar features of antigens recognized by B or T cells. The chap and Antigen(rig ter also explores the contribution made to immunogenicity by the biological system of the host; ultimately the biological system determines whether a molecule that combines with a a Immunogenicity Versus Antigenicity Bor T cells antigen-binding receptor can then induce an im

that peptides derived from the antigen be displayed within the cleft of an MHC peptide-Mhcthe m ormation of the Antigen Processing for Presentation by Class I MHC Molecules Self-MHC Restriction of T Cells Class tides that Role of Antigen-Presenting Cells Evidence for Two Processing and Presentation Pathways

Kappa Light-Chain Gene Rearrangement the vertebrate immune system is its ability to respond to an apparently limitless array of for eign antigens As immunoglobulin(Ig)sequence data accu- a Genetic Model Compatible with Ig Structure mulated, virtually every antibody molecule studied was found to contain a unique amino acid sequence in its vari a Multigene Organization

(一)名词的固定搭配 介词+名词形式 第一组 by accident偶然 on account of因为,由于 in addition另外 in addition to除之外(包括 in the air在流行中,在传播中 onthe/an)average平均,一般来说 on the basis of根据,在的基础上 at(the)best充其量,至多

Branch of discovery science focusing on proteins In 1994 defined as the complete set of proteins that is expressed and modified following expression by the entire genome in the lifetime of a cell. If we look at an organism it means that we are looking at the proteome of 3 trillion of cells and -1000

General considerations Definition In placenta previa, the placenta is implanted in the lower uterine segment and located over the internal os. It constitutes an obstruction of descent of the presenting part. Main cause of obstetrical hemorrhage Incidence 0.24%-1.57% (our country)

How do we maneuver ImagestakenfromNasa'Swebsitehttp://www.nasa.gov/ Roadmaps are an effective state space abstraction Brian Williams, Spring 0 Courtesy of U.S. Geological survey

Outline Objectives Agents and Their building Blocks Principles for building agents Modeling formalisms Algorithmic Principles Building an agent: The Mars Exploration rover

Achieving Arc Consistency via Constraint Propagation Arc consistency eliminates values of each variable domain that can never satisfy a particular constraint (an arc Directed arc (Vi, v) is arc consistent if VXED, 3yED, such that(x, y) is allowed by constraint C

Outline The promise of autonomous explorers The challenge of autonomous explorers Agents great and small Course objective 1(16.410/13) Principles for Building Agents Course objective 2(16.413) Building an Agent The Mars exploration rover(MEr) project