Lecture 17: Drug targeting Last time Intracellular drug de Today Drug targeting Reading T.J. Wickham, 'Ligand-directed targeting of genes to the site of disease, Nat. Med. 9(1) 135-139(2003)

Biodegradable Solid Polymers Spring 2003 Issued Day 1 5 points/problem(20 points total) 1. The chemical structure of a new degradable polymer, poly(ethylene glycol)-b-polylysine-b- poly (D, L-lactide), is shown below a. Based on chemical structure al

1. An early study in the development of peptide-presenting biomaterials showed that polymer surfaces bearing RGD peptides at a density equivalent to -10 peptides per each cell was sufficient to promote cell attachment, spreading and subsequent cell growth. In contrast, when whole

1. Re-derive the equation for equilibrium swelling of a polyelectrolyte gel where the polymer chains contain a basic ionizable group that becomes positively charged with decreasing pH

1. Re-derive the equation for equilibrium swelling of a polyelectrolyte gel where the polymer chains contain a basic ionizable group that becomes positively charged with decreasing pH

Biodegradable Solid Polymers Spring 2003 Issued Day 1 Day 3 1. The chemical structure of a new degradable polymer, poly (ethylene glycol)-b-polylysine-b- poly (D, L-lactide)

BIOMATERIALS-TISSUE INTERACTIONS BIOMATERIAL TISSUE Strength ize scale IOnm 100nm lum 10 um 100 um Imm Modulus of Elasticity Fracture mechanics

B. Cell-Matrix Interactions A. How cells pull onto and deform the matrix to which they attach themselves. B. Cell-matrix interactions control the spontaneous closure of wounds in organs. C. What happens when regeneration is induced?

C. Cell-Matrix Interactions A. How cells pull onto and deform the matrix to which they attach themselves. B. Cell-matrix interactions control the spontaneous closure of wounds in organs. C. What happens when regeneration is induced?

《工程科学学报》：生物质多孔碳基复合相变材料制备及性能