自然辩证法是马克思主义哲学的一个分支学 科,是人们借以认识自然界和改造自然界的辩 证思维方式,是关于自然界和科学技术发展的 一般规律以及人们认识自然和改造自然的一般 方法的科学

 掌握基因概念及结构特点；中心法则；基因转录调控相关序列；多顺反子，单顺反子；真核基因与原核基因的结构特点。  熟悉基因突变的意义  了解基因命名法

9.1 Introduction 9.2 Transcription is catalyzed by RNA polymerase 9.3 The transcription reaction has three stages 9.4 A stalled RNA polymerase can restart 9.5 RNA polymerase consists of multiple subunits 9.6 RNA Polymerase consists of the core enzyme and sigma factor 9.7 Sigma factor is released at initiation 9.8 Sigma factor controls binding to DNA 9.9 Promoter recognition depends on consensus sequences

• 8.3 蛋白质磷酸化对基因转录的调控 • 8.4 蛋白质乙酰化对基因表达的影响 • 8.5 激素与热激蛋白对基因表达的影响 • 8.6 其他水平上的表达调控

7. 1 原核基因表达调控总论 7. 2 乳糖操纵子与负控诱导系统 7. 3 色氨酸操纵子 7. 4 操纵子的其它调控形式 7.5 转录水平上的其他调控方式 7.6 翻译的调控

23.1 Introduction 23.2 Group I introns undertake self-splicing by transesterification 23.3 Group I introns form a characteristic secondary structure 23.4 Ribozymes have various catalytic activities 23.5 Some introns code for proteins that sponsor mobility 23.6 The catalytic activity of RNAase P is due to RNA 23.7 Viroids have catalytic activity 23.8 RNA editing occurs at individual bases

22.1 Introduction 22.2 Nuclear splice junctions are short sequences 22.3 Splice junctions are read in pairs 22.4 Nuclear splicing proceeds through a lariat 22.5 snRNAs are required for splicing 22.6 U1 snRNP initiates splicing 22.7 The E complex can be formed in alternative ways 22.8 5 snRNPs form the spliceosome

21.1 Introduction 21.2 Response elements identify genes under common regulation 21.3 There are many types of DNA-binding domains 21.4 A zinc finger motif is a DNA-binding domain 21.5 Steroid receptors are transcription factors 21.6 Steroid receptors have zinc fingers 21.7 Binding to the response element is activated by ligand-binding 21.8 Steroid receptors recognize response elements by a combinatorial code

第一节 基因表达调控的基本概念 第二节 转录水平的调控－操纵子 第三节 转录后加工的调控 第四节 翻译水平的调控

3.1 RNA的转录 3.2 启动子与转录起始 3.3 原核与真核生物mRNA的特征比较 3.4 RNA Pol I和Pol III介导的基因转录 3.5 内含子的剪接、编辑及化学修饰