一、抗菌药物的体内过程 1.吸收吸收过程药时曲线AUC生物利用度 2.分布表观分布容积分布特性(骨、前列腺、脑脊液、胎儿) 3.消除血浆半衰期(t12)肝、肾消除胆汁 二、药动学(PK)-药效学结合模型(PD)

一、化学药,生物药:(资料27) 1类,全新:单次(3个剂量),多次,口服者加食物影响,CT曲线药代特征药代参数组织分布蛋白结合,消除特征(尿,粪胆),结构转化药酶影响 2类,新途:第20条说明速缓控释者做单次多次 4类,改根:单次为主 5类,改型:同2类新途

一、什么是临床药动学? 二、临床药动学有哪些研究内容? 三、临床药动学研究与药物临床应用有何关系? 四、新药临床药动学研究有哪些基本要求? 五、新药临床药动学研究记录与保存文件有哪些要求?

一、消化腺 二、唾液腺 三、胰腺 四、肝

概述 一、组成—鼻、咽、喉、气管、支气管、肺 二、功能 导气:鼻→肺的终末细支气管气体交换:肺的呼吸性细支气管→肺泡 嗅觉:鼻嗅部 发音:喉 内分泌:散在

Introduction Growth and growth disorders Adrenal disorders and sexual development abnormalities Thyroid disorders Disorders of calcium and phosphorus metabolism Diabetes mellitus and hypoglycemia Other disorders: obesity, autoimune

Introduction Growth and growth disorders Adrenal disorders and sexual development abnormalities Thvroid disorders Disorders of calcium and phosphorus metabolism Diabetes mellitus and hypoglycemia Other disorders: obesity, autoimune endocrinopathies, tumor, inborn metabolic

One pairofchromosome 21 was seen in peripheral lymphocytes of normal person 15

Congenital Heart Diseases (CHD)先天性心脏病 General concept CHD occurs in approximately6-8‰ live births In China, alone 250000 children with CHD are b0r€aC1yaT 30% of cases may die within first year of life The etiology remains unsolved Secondary prevention is the strategy at this stage

Causation and Treatment Professor of Obstetrics, Northwestern University Medical School Jos. B. De Lee Published in Medicine (Detroit) 3: 643-660, 1897. The highest mortality that befalls the human race in one day occurs on the day of birth. It is said that the most important period of the life of a human being is the time spent in utero. The most trying ordeal a human being sustains is the ordeal of birth