The physiological consequence of KM:Km生理学意义 The sensitivity of some persons to ethanol..酒精敏感人群 Alcohol dehydrogenane Liver CHCH2OH NAD CH CHO H+NADH the cause of the symptoms CH2CHO is processed to acetate by aldehyde dehydrogenase 乙醛能为7醛脱氢醢降解。 Aldehyde dehydrogenase CH;CHO NAD*+H2O= CH COO-NADH +2 H+ Two forms of the aldehyde dehydrogenase:两套酶系统 一a low KM mitochondrial form较低底物浓度就可以启动反应 -a high KM cytoplasmic form. In susceptible persons,the mitochondrial enzyme is less active owing to the substitution of a single amino acid.The sensitivity of some persons to ethanol. 酒精敏感人群 Liver CH3CHO is processed to acetate by aldehyde dehydrogenase. 乙醛能为乙醛脱氢酶降解。 Two forms of the aldehyde dehydrogenase：两套酶系统 － a low KM mitochondrial form 较低底物浓度就可以启动反应 － a high KM cytoplasmic form. The physiological consequence of KM: Km生理学意义 In susceptible persons, the mitochondrial enzyme is less active owing to the substitution of a single amino acid. the cause of the symptoms