Reactions of Carboxylic Acids(and Derivatives) Ketones and aldehydes have a carbonyl group and undergo nucleophilic addition,whereas carboxylic acids(and their derivatives)under nucleophilic acyl substitution-this is where one nucleophile replaces another on the acyl carbon. E.g. Nucleophilic acyl substitution RC-X +Nuc: R-C-Nuc+X Acid derivatives 0 ○ R一COH R一C-X -O-CR carboxylic acid acyl halide anhydride este amide Carboxylic acid derivatives differ in the nature of the group bound to the acyl group. -OH is an acid -Cl is the acid chloride -OCOR'is the anhydride -OR'is the ester -NR2 is the amide Nucleophilic acyl substitution can interconvert all of these different acid derivatives Ch20 Carboxylic Acids (landscape) Page 17Ch20 Carboxylic Acids (landscape) Page 17 Reactions of Carboxylic Acids (and Derivatives) Ketones and aldehydes have a carbonyl group and undergo nucleophilic addition, whereas carboxylic acids (and their derivatives) under nucleophilic acyl substitution - this is where one nucleophile replaces another on the acyl carbon. E.g. Carboxylic acid derivatives differ in the nature of the group bound to the acyl group. -OH is an acid -Cl is the acid chloride -OCOR' is the anhydride -OR' is the ester -NR2 is the amide Nucleophilic acyl substitution can interconvert all of these different acid derivatives