1758· Anhui Medical and Pharmaceutical Journal 2017 Oct, 21(10) al abnormalities in mood disorders: implications for neurocircuitry [39] Network and pathway analysis subgroup of Psychiatric Genomics models of depression [. Brain Struct Funct, 2008, 213(1/2): 9318 Consortium. Psychiatric genome-wide association study analyses [23] VICTOR TA, FUREY ML, FROMM S], et al. Relationship of emo- implicate neuronal, immune and histone pathways []. Nat Neuros- tional processing to masked faces in the amygdala to mood state 015,18(12):1861 and treatment in major depressive disorder []. Arch Gen Psychia- [40] CHEN H, PANDEY GN, DWIVEDI Y Hippocampal cell prolifera- ry,2010,67(11):1128-138 tion regulation by repeated stress and antidepressants []. Neurore- 124] BELLANI M, BAIANO M, BRAMBILLA P Brain anatomy of m port,2006,17(9):863867 nygdala [J]. Epidemiol Psychia 41] LIU RJ, LEE FS, LI XY, et al. Brain-derived neurotrophic factor 2011,20(1):3 Val66 Met allele impairs hasal and ketaminestimulated synaptogenesis 25] DEAKIN JFW, Graeff FG 5-HT and mechanisms of defense D.J in prefrontal cortex []. Biod Psychiatry, 2012,71(11): 996-005. 42] GATT JM, NEMEROFF CB, DOBSON-STONE C, et al. Interac- 126] JOCASAMIA RL, FERREIRA FR, GUIMARAE FS Modulation of tions between BDNFVal66 Met polymorphism and early-ifestress stress co by hippocampal monoaminergic, glutamatergic and predict brain and arousal pathways to syndromal depression and nitrergic neurotransmitter systems D]. Stress, 2007, 10(3): 227-249 anxiety [. Mol Psychiatry, 2009, 14(7): 6814695 27] JOCA SR, ZANELATI T, GUIMARAES FS Post-stress facilitation 43] MENKE A, BINDER EB. Epigenetic alterations in depression and of serotonergic, but not noradrenergic neurotransmIssion antidepressant treatment []. Dialogues Clin Neurosci, 2014,16 dorsal hippocampus prevents learned helplessness development in (3):395-04. rats [l. Brain Res, 2006, 1087(1): 67-74 44] NESTLER EJ. Epigenetic mechanisms of depression [].JAMA 28] MACQUEEN GM, CAMPBELL S, MCEWEN BS,et al. Course of ill Psychiatry,2014,71(4):454456. ness,hippocampal function, and hippocampal volume in major de- [45] DIAS BG, MADDOX SA, KLENGEL T, et al. Epigenetic mecha ression Proc Natl Acad Sci USA, 2003, 100(3): 1387-392 ms underlying learning and the inheritance of learned behaviors 29] FRODL T, MEISENZAHL EM, ZETZSCHE T, et al. Hippocampal L. Trends Neurosci, 2015, 38(2): 9607 and amygdale changes in patients with major depressive disorder 46] KRISHNAN V, NESTLER EJ. The molecular neurobiology of de- and healthy controls during a l-year follow-up [l. J Clin Psychia pression. Nature,2008,455(7215):894-02. ry,2004,65(4):492499 47] CASPI A, SUGDEN K, MOFFTTT TE, et al. Influence of life stress B30] NEUMEISTER A, WOOD S, BONNE O, et al. Reduced hippocampal on depression: moderation by a polymorphism in the 5-HTT gene volume in unmedicated, remitted patients with major depression . Science,2003,301(5631):386-89 control subjects [l. Biol Psychiatry, 2005, 57(8): 93537 48] HOLLY EN, MICZEK KA. Ventral tegmental area dopamine B1] RAO U, CHEN LA, BIDESI AS, et al. Hippocampal changes as ted: effects of acute and repeated stress []. Psychopharmacology ciated with earlyHife adversity and vulnerability to depression Dl (Berl),2016,233(2):163486 Biol Psychiatry, 2010, 67 (4): 357-364. 49] MCEWEN BS. Stress and hippocampal plasticity [I.Annu Rev cuit in depression Biol Psychiatry, 2006, 59(12): 1151+159. 50] HEIM C, NEWPORT D], HEIT S, et al. Pituitary-adrenal and auto- 33] GRACE AA. Dysregulation of the dopamine system in the patho- nomic responses to stress in women after sexual and physical abuse iology of schizophrenia and depression [. Nat Rev Neurosci in childhood [n. JAMA, 2000, 284(5): 592-597 2016,17(8):524532 [1] NEWPORT D], HEIM C, BONSALL R,et al. Pituitary -adrenal respon- B34 TULLBERG M, FLETCHER E, DECARLI C, et al. White matter ses to standard and low -lose dexamethasone suppression tests in adult lesions impair frontal lobe function regardless of their location D survivors of child abuse i. Biol Psychiatry, 2004, 55(1): 10-20 neurology,2004,63(2):246253 52 MODELL S, LAUER C], SCHREIBER W, et al. Hormonal re- B5 ZHU X, WANG X, XIAO J, et al. Altered white matter integrity in sponse pattern in the combined DEX-CRH test is stable over time first-episode, treatment-mlaive young adults with major depressive in subjects at high familial risk for affective disorders [].Neuro- disorder:a tract-based spatial statistics study [J].Brain Res psychopharmacology, 1998,18(4): 253-262 2011,1369:22329 53] WONG ML, LICINIO J. From monoamines to genomic targets: a 36] HANNESTAD J, TAYLOR WD, MCQUOID DR,et al. White mat- paradigm shift for drug discovery pression []. Nature Rev ter lesion volumes and caudate volumes in late ife depression [n] Drug disc,2004,3(2):136451 Int J Geriatr Psychiatry, 2006,21(12): 1193-198 54] CASTREN E. Is mood chemistr? []. Nature Reviews Neuro 37 DUNN EC, BROWN RC, DAI Y, et al. Genetic determinants of de 2005,6(3):241-4 pression: recent findings and future directions []. Hary Rev Psy- [55] SVENNINGSSON P, KARIMA C, ILAN R, et al. Alterations in 5 chiatry,2015,23(1) HTI B receptor function by pll in depression ike states [].Sci- B8] LEVINSON DF, MOSTAFAVI S, MILANESCHE Y, et al. Genetic ence,2006,311(5757):77-80. studies of major depressive disorder: why are there no genome-w [56] LIU RJ, AGHAJANIAN GK. Stress blunts serotonin- and hypocre- association study findings and what can we do about ie [].Biol tinevoked EPSCs in prefrontal cortex: role of corticosterone-tmedia- Psychiatry,2014,76(7):510-12 ted apical dendritic atrophy [I. Proc Natl Acad Sci USA, 2008 21994-2017ChinaAcademicJOurnalElectronicpUblishingHouse.Allrightsreservedhttp:/www.cnki.netal abnormalities in mood disorders: implications for neurocircuitry models of depression［J］． Brain StructFunct，2008，213( 1/2) : 93-118． ［23］ VICTOＲ TA，FUＲEY ML，FＲOMM SJ，et al． Ｒelationship of emo￾tional processing to masked faces in the amygdala to mood state and treatment in major depressive disorder［J］． Arch Gen Psychia￾try，2010，67( 11) : 1128-1138． ［24］ BELLANI M，BAIANO M，BＲAMBILLA P． Brain anatomy of major depression II． Focus on amygdala［J］． Epidemiol Psychiatr Sci， 2011，20( 1) : 33-36． ［25］ DEAKIN JFW，Graeff FG． 5-HT and mechanisms of defense［J］． J Psychopharmacol，1991，5( 4) : 305-315． ［26］ JOCASAMIA ＲL，FEＲＲEIＲA FＲ，GUIMAＲAE FS． Modulation of stress consequences by hippocampal monoaminergic，glutamatergic and nitrergic neurotransmitter systems［J］． Stress，2007，10( 3) : 227-249． ［27］ JOCA SＲ，ZANELATI T，GUIMAＲES FS． Post-stress facilitation of serotonergic，but not noradrenergic，neurotransmission in the dorsal hippocampus prevents learned helplessness development in rats［J］． Brain Ｒes，2006，1087( 1) : 67-74． ［28］ MACQUEEN GM，CAMPBELL S，MCEWEN BS，et al． Course of ill￾ness，hippocampal function，and hippocampal volume in major de￾pression［J］． Proc Natl Acad Sci USA，2003，100( 3) : 1387-1392． ［29］ FＲODL T，MEISENZAHL EM，ZETZSCHE T，et al． Hippocampal and amygdale changes in patients with major depressive disorder and healthy controls during a 1-year follow-up［J］． J Clin Psychia￾try，2004，65( 4) : 492-499． ［30］ NEUMEISTEＲ A，WOOD S，BONNE O，et al． Ｒeduced hippocampal volume in unmedicated，remitted patients with major depression ver￾sus control subjects［J］． Biol Psychiatry，2005，57( 8) : 935-937． ［31］ ＲAO U，CHEN LA，BIDESI AS，et al． Hippocampal changes asso￾ciated with early-life adversity and vulnerability to depression［J］． Biol Psychiatry，2010，67( 4) : 357-364． ［32］ NESTLEＲ EJ，CAＲLEZON WA． The mesolimbic dopamine reward cir￾cuit in depression［J］． Biol Psychiatry，2006，59( 12) : 1151-1159． ［33］ GＲACE AA． Dysregulation of the dopamine system in the patho￾physiology of schizophrenia and depression［J］．Nat Ｒev Neurosci， 2016，17( 8) : 524-532． ［34］ TULLBEＲG M，FLETCHEＲ E，DECAＲLI C，et al． White matter lesions impair frontal lobe function regardless of their location［J］． Neurology，2004，63( 2) : 246-253． ［35］ ZHU X，WANG X，XIAO J，et al． Altered white matter integrity in first-episode，treatment-nave young adults with major depressive disorder: a tract-based spatial statistics study［J］． Brain Ｒes， 2011，1369: 223-229． ［36］ HANNESTAD J，TAYLOＲ WD，MCQUOID DＲ，et al． White mat￾ter lesion volumes and caudate volumes in late-life depression［J］． Int J Geriatr Psychiatry，2006，21( 12) : 1193-1198． ［37］ DUNN EC，BＲOWN ＲC，DAI Y，et al． Genetic determinants of de￾pression: recent findings and future directions［J］． Harv Ｒev Psy￾chiatry，2015，23( 1) : 1-18． ［38］ LEVINSON DF，MOSTAFAVI S，MILANESCHE Y，et al． Genetic studies of major depressive disorder: why are there no genome-wide association study findings and what can we do about it? ［J］． Biol Psychiatry，2014，76( 7) : 510-512． ［39］ Network and pathway analysis subgroup of Psychiatric Genomics Consortium． Psychiatric genome-wide association study analyses implicate neuronal，immune and histone pathways［J］． Nat Neuros￾ci，2015，18( 12) : 1861． ［40］ CHEN H，PANDEY GN，DWIVEDI Y． Hippocampal cell prolifera￾tion regulation by repeated stress and antidepressants［J］． Neurore￾port，2006，17( 9) : 863-867． ［41］ LIU ＲJ，LEE FS，LI XY，et al． Brain-derived neurotrophic factor Val66Met allele impairs basal and ketamine-stimulated synaptogenesis in prefrontal cortex［J］． Biol Psychiatry，2012，71( 11) : 996-1005． ［42］ GATT JM，NEMEＲOFF CB，DOBSON-STONE C，et al． Interac￾tions between BDNFVal66Met polymorphism and early-lifestress predict brain and arousal pathways to syndromal depression and anxiety［J］． Mol Psychiatry，2009，14( 7) : 681-695． ［43］ MENKE A，BINDEＲ EB． Epigenetic alterations in depression and antidepressant treatment［J］． Dialogues Clin Neurosci，2014，16 ( 3) : 395-404． ［44］ NESTLEＲ EJ． Epigenetic mechanisms of depression［J］． JAMA Psychiatry，2014，71( 4) : 454-456． ［45］ DIAS BG，MADDOX SA，KLENGEL T，et al． Epigenetic mecha￾nisms underlying learning and the inheritance of learned behaviors ［J］． Trends Neurosci，2015，38( 2) : 96-107． ［46］ KＲISHNAN V，NESTLEＲ EJ． The molecular neurobiology of de￾pression［J］． Nature，2008，455( 7215) : 894-902． ［47］ CASPI A，SUGDEN K，MOFFITT TE，et al． Influence of life stress on depression: moderation by a polymorphism in the 5-HTT gene ［J］． Science，2003，301( 5631) : 386-389． ［48］ HOLLY EN，MICZEK KA． Ventral tegmental area dopamine revisi￾ted: effects of acute and repeated stress［J］． Psychopharmacology ( Berl) ，2016，233( 2) : 163-186． ［49］ MCEWEN BS． Stress and hippocampal plasticity［J］． Annu Ｒev Neurosci，1999，22: 105-122． ［50］ HEIM C，NEWPOＲT DJ，HEIT S，et al． Pituitary-adrenal and auto￾nomic responses to stress in women after sexual and physical abuse in childhood［J］． JAMA，2000，284( 5) : 592-597． ［51］ NEWPOＲT DJ，HEIM C，BONSALL Ｒ，et al． Pituitary-adrenal respon￾ses to standard and low-dose dexamethasone suppression tests in adult survivors of child abuse［J］． Biol Psychiatry，2004，55( 1) : 10-20． ［52］ MODELL S，LAUEＲ CJ，SCHＲEIBEＲ W，et al． Hormonal re￾sponse pattern in the combined DEX-CＲH test is stable over time in subjects at high familial risk for affective disorders［J］． Neuro￾psychopharmacology，1998，18( 4) : 253-262． ［53］ WONG ML，LICINIO J． From monoamines to genomic targets: a paradigm shift for drug discovery in depression［J］． Nature Ｒev Drug Disc，2004，3( 2) : 136-151． ［54］ CASTＲN E． Is mood chemistry? ［J］． Nature Ｒeviews Neuro， 2005，6( 3) : 241-246． ［55］ SVENNINGSSON P，KAＲIMA C，ILAN Ｒ，et al． Alterations in 5- HT1B receptor function by p11 in depression-like states［J］． Sci￾ence，2006，311( 5757) : 77-80． ［56］ LIU ＲJ，AGHAJANIAN GK． Stress blunts serotonin- and hypocre￾tin-evoked EPSCs in prefrontal cortex: role of corticosterone-media￾ted apical dendritic atrophy［J］． Proc Natl Acad Sci USA，2008， ·1758· 安 徽 医 药 Anhui Medical and Pharmaceutical Journal 2017 Oct，21( 10)