心血管疾病的发生机理 上游充通大粤 SHANGHAI JIAO TONG UNIVERSITY Distribution of atherosclerosis Initialization and progression of atherosclerosis Proximal ATHEROSCLEROSIS Stages of development Sultan Chaudhry Endothelial dysfunction Fatty streak ·T恒s咖路 Lipoprotein entry and modification Mid-proximal development ·↑LDL concentration ·Sne Distal This inflammatory response takes decades and is reversible Leukocyte recruitment Foam cell formation Monocyesngf the midired LDL nofathesion moleclesand and became foam cel's tee3se甘e■的结1性 Intima continues to Plaque thicken due to Evolution of the fatty streak progression ·TSMC prlferaion and calcification ·↑ekocye recritmen Luminal narrowing Fibrous capsule fow limitation ·p时ich care5wru6yts capsule 1.Claudication 2.Angina Smited fow in wng销回e Plaque Plaque size vs.stability ,Tid馆配ous cosules caus转ma年namwing bet are more stab线 disruption ACS DeBakey et al.,Ann Surg.201(2):115-131,1985. [Lusis AJ,.Nature.407,233-241,2000; A statistical study based on data in 13827 patients Libby P.Nate.420(6917):868-74,2002.]88 DeBakey et al., Ann Surg. 201(2): 115–131,1985. A statistical study based on data in 13827 patients Distribution of atherosclerosis [Lusis AJ, Nature. 407, 233-241, 2000; Libby P. Nature. 420(6917):868-74, 2002.] Initialization and progression of atherosclerosis 心血管疾病的发生机理